DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Gucy2d

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	339	Identity:	126/339 - (37%)
Similarity:	182/339 - (53%)	Gaps:	48/339 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 ETDRILFQC---YPSVMNLDDLT---KKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLT 483
            |..:::.||   :|.:....|||   .||:        :..|...::........:.:.|||
  Rat   782 ECIQLMAQCWAEHPELRPSMDLTFDLFKGI--------NKGRKTNIIDSMLRMLEQYSSNLE--- 835

  Fly   484 DKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANT 548
            |.:::...:||.|||||||||..:||.|||..|:....|.|:.::.|||.||.|||| ...:|.:
  Rat   836 DLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGF-TTISAMS 899

  Fly   549 DPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPD-HCEDHAKCMARVALD 612
            :|   :::|.:||:|||:|||:..|.   :||||||:||.||..||||. :.:.||..:|.::||
  Rat   900 EP---IEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLD 958

  Fly   613 MMDMAKNVK---MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINV 674
            ::....:.:   |...||:|.||:|||..|.||:|..:|||||||:|||..||.|:||:|.||:|
  Rat   959 ILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHV 1023

  Fly   675 SEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGGNGSL 739
            :..|.|:| .|:  |..|.:|.||...:|||......|.:.|.                |.|..:
  Rat  1024 NMSTVRIL-RAL--DQGFQMECRGRTELKGKGVEDTYWLVGRV----------------GFNKPI 1069

  Fly   740 DSPL-LQPATPTAG 752
            ..|. |||.....|
  Rat  1070 PKPPDLQPGASNHG 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	30/96 (31%)
		CYCc	496..688	CDD:214485	93/195 (48%)
		Guanylate_cyc	522..714	CDD:278633	87/195 (45%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552
		PK_GC-2D	540..814	CDD:270945	9/39 (23%)
		HNOBA	<823..868	CDD:400168	20/47 (43%)
		CYCc	848..1039	CDD:214485	94/200 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810