DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Gucy2g

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	243	Identity:	94/243 - (38%)
Similarity:	151/243 - (62%)	Gaps:	15/243 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 KLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIV 538
            ||......|.:.:::..|:|.:||:|.::||.::||..|..:|...:.|.|:.::|||:.||.||
Mouse   844 KLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIV 908

  Fly   539 GFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP-DHCEDH 602
            ||.:.|:.::    .:::||:||:||::||....|.   :||||||:||.||..|||| .:...|
Mouse   909 GFTKLCSLSS----PLQVVKLLNDLYSLFDHTIQSH---DVYKVETIGDAYMVASGLPIRNGAQH 966

  Fly   603 AKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTE 664
            |..:|.:||.::.:..:.::|..|   :::.||:|:|.||.||:|..:|||||||:|||:.||.|
Mouse   967 ADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRME 1031

  Fly   665 TTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCW 712
            ::.:|.||:||:.|...|..|    ..:||:.||.:.:|||......|
Mouse  1032 SSSLPLRIHVSQSTAGALLAA----GGYHLQKRGTISVKGKGEQTTFW 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	13/41 (32%)
		CYCc	496..688	CDD:214485	81/195 (42%)
		Guanylate_cyc	522..714	CDD:278633	80/195 (41%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894
		CYCc	865..1055	CDD:214485	81/200 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810