DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	682	Identity:	210/682 - (30%)
Similarity:	333/682 - (48%)	Gaps:	148/682 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLY--- 112
            ::.....:|.:...:|.|.||:.||:.|.|.. :::|:.:|:|.:||....|||.:|:.|.:
  Rat   152 ILRCTANVLGLKFQEIQERFGEEFFKICFDEN-ERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQ 215

  Fly   113 PGMRAPSFRCTE-KDGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAE 176
            ..:.:|||.|.| .:|.|.|||:.....:...::|::||...:::.:.||::.:
  Rat   216 ATLESPSFLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQI----------- 269

  Fly   177 KERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNN 241
                   ||::...|                           ||..||
  Rat   270 -------ENEKFCSD---------------------------GSTPSN----------------- 283

  Fly   242 DGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVA-AK 305
                                                            |..:.|||:|.... ..
  Rat   284 ------------------------------------------------YSCLTFLIKECETTQIT 300

  Fly   306 SQVDAKKDEVPDDMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVI----PRVAE- 365
            ..:.....::|.|:.       ||..|||:.||||||||..|.::|.|:.:.:.:    .:|.:
  Rat   301 KNIPQGTSQIPTDLR-------ISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLRCDNHKVLKF 358

  Fly   366 ENCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRIL 430
            |:|     .|.:.|.:...|:.:|..::|.:|::|:..|..:.:|.:.:.:||||:::||::.||
  Rat   359 EDC-----FEIVSPKVNATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAIL 418

  Fly   431 FQCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLES 495
            |...|.|..||:|..:||::||:|:|||.||::|:.|:.:|:..|.|.::.|...|::|.:.||.
  Rat   419 FLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEE 483

  Fly   496 EKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKML 560
            ||:||..||||:.|..||.:|..::.|..:::|.||::||.||||...||..|    .|:::.||
  Rat   484 EKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVGFTAICAQCT----PMQVISML 544

  Fly   561 NELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV-KMGS 624
            |||||.||.....   |::|||||:||.|...|||......|||.:|.:||.||::::.| ....
  Rat   545 NELYTRFDHQCGF---LDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDG 606

  Fly   625 NPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQD 689
            .|:|:.||||||.|:.||:|.|:||||||||.|.|.|:.|:...|.|||:|..||:||    .::
  Rat   607 RPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISPTTYQLL----KRE 667

  Fly   690 DSFHLEYRGPVIMKG---KPTPMDCWFLTRAT 718
            |||....|....:..   |..|..|:||...|
  Rat   668 DSFTFIPRSREELPDNFPKEIPGVCYFLELRT 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	34/116 (29%)
		HNOBA	326..516	CDD:285003	73/194 (38%)
		CYCc	496..688	CDD:214485	90/192 (47%)
		Guanylate_cyc	522..714	CDD:278633	85/195 (44%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002	34/111 (31%)
		HNOBA	314..501	CDD:285003	71/198 (36%)
		CYCc	483..672	CDD:214485	93/199 (47%)
		Guanylate_cyc	512..696	CDD:278633	85/194 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820