Protein Alignment Gycbeta100B and Gucy1a1

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001343916.1
• Gene: Gucy1a1 / 60596
• MGIID: 1926562
• Length: 691
• Species: Mus musculus
• Alignment Length: 762
• Identity: 212/762 - (27%)
• Similarity: 326/762 - (42%)
• Gaps: 202/762 - (26%)

  Fly     5 VNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILEL 69
            :|.||:..:.||..||     .:|   |.|.:.|.:.|.::.|.   .||.||.|.       :.
Mouse    89 LNLALQRTLAKHKIEE-----NRK---SSEKEDLEKIIAEEAIA---AGAPVEALK-------DS 135

  Fly    70 FGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDAL-----HDHLGTLYPGMRAPSFRCTEKDGEL 129
            .|:..|:.|.:.. :.||.|:|.|.:|||.:...|     |.........:...|..|.:||.:.
Mouse   136 LGEELFKICYEED-EHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCLDKDQDF 199

  Fly   130 L-LHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            | ::|:..:.....::.||:||.|..|:...||:.::
Mouse   200 LNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLM---------------------------- 236

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                             
Mouse   237 ----------------------------------------------------------------- 236

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLC 323
                           ..|.|      .|...:.:..:|:..::|  ||...:.....|
Mouse   237 ---------------PPCFR------SDCTEFVNQPYLLYSVHV--KSTKPSLSPGKP------- 271

  Fly   324 EAPLISPAT-FCKVFPFHLMFDRQMKIVQAGKAVSRVI-PRVAEENCSLIEVVEAIRPHLQLNFE 386
            ::.|:.||: |||.||||.|.||.:.|:|.|..:.|:: .|..:...:..|..|.:.|.:...|.
Mouse   272 QSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQTFS 336

  Fly   387 NILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYIS 451
            .|::.:|..:|::.|:...|.:...|.:.|||||:||.|:..|||...|.|..|:|.|.:|||:|
Mouse   337 GIMTMLNMQFVIRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLS 401

  Fly   452 DVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANEL 516
            |:|:|:|.||:||:.|:..|:..|.|.|..|...|:...:.||.||::|..||.|:.|..||.:|
Mouse   402 DIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQL 466

  Fly   517 RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYK 581
            ...:.|..|::..||::||.||||...| :...|   ::::.|||.|||.||   .....|:|||
Mouse   467 WQGQIVQAKKFSEVTMLFSDIVGFTAIC-SQCSP---LQVITMLNALYTRFD---QQCGELDVYK 524

  Fly   582 VETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV-KMGSNPVQITIGIHSGEVVTGVIGN 645
            |||:||.|....||....:.||..:|.:||.||:::..| .....|:::.||:|||.|..||:|.
Mouse   525 VETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGV 589

  Fly   646 RVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLL---------------------------C 683
            ::||||||||.|.|.::.|:..||.:||||..|||||                           |
Mouse   590 KMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSDIPGIC 654

  Fly   684 MAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTR----ATSSILGGTS 726
            ..:   |::|  ::||   ..||     ||..:    ..::.||..|
Mouse   655 HFL---DAYH--HQGP---NSKP-----WFQDKDVEDGNANFLGKAS 688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	45/164 (27%)
		HNOBA	326..516	CDD:285003	74/191 (39%)
		CYCc	496..688	CDD:214485	83/219 (38%)
		Guanylate_cyc	522..714	CDD:278633	80/219 (37%)
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	73/188 (39%)
		Guanylate_cyc	472..643	CDD:306677	72/177 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810