DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Phlpp1

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_038946976.1	Gene:	Phlpp1 / 59265	RGDID:	621308	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	702	Identity:	142/702 - (20%)
Similarity:	233/702 - (33%)	Gaps:	203/702 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 RAPSFRCTEKDGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEI-----DIVKRKGEPID-- 173
            :||    |..||..|:  ..|.||.:       ||||:...||.:..     :.|::...|..
  Rat   384 KAP----TGVDGTGLV--VGEGPGDD-------KAVAAAAPGVPLWTPGRIRETVQKTSSPPSLY 435

  Fly   174 ---EAEKERAIARENQ--QLLEDAVATTTTGSATVVLAPSSDAE--------RNNNHNGSNGSNN 225
               ..|..|.:..:.:  |:..|.:.....|....|.....|:|        ....|  |.||:.
  Rat   436 VQLHGETTRRLEADEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPH--STGSSE 498

  Fly   226 ----NGMAN--NGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKS 284
                :||.|  .|......|....:|:       |...||.|.....|....| ...|.|:..|.
  Rat   499 RIQLSGMYNVRKGKMQLPVNRWTRRQV-------ILCGTCLIVSSVKDSSSGK-MHVLPLIGGKV 555

  Fly   285 DDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISPATFC-KVFPFHLMFDRQMK 348
            ::::::.|.                         :.|....|.......| ..|..:|.:.||:
  Rat   556 EEVKKHQHC-------------------------LAFSSSGPQSQTYYICFDTFTEYLRWLRQV- 594

  Fly   349 IVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLN--FENILSHINTIY-VLQTRQGAMSSR-- 408
                .|..|:.|..|....|||        .||..|  :...|:|:|... .|:......::|
  Rat   595 ----SKVASQRISSVDLSCCSL--------EHLPANLFYSQDLTHLNLKQNFLRQNPSLPAARGL 647

  Fly   409 -HEQRFLRLK-------------GQMMYIPETDRILFQC---------YPSVMNLDDLTKKGLYI 450
             ..|||.:||             ..:..||....:...|         ..::.||......|.::
  Rat   648 GELQRFTKLKSLNLSNNHLGAFPSAVCSIPTLAELNVSCNALREVPAAVGAMQNLQTFLLDGNFL 712

  Fly   451 SDVPLH-DAARDLVLLSEKFEAEYKLTKNLEMLT--DKLQQTFRDLESEKQKTDR---------L 503
            ..:|.. :....|..|...|.....:.:.||.||  |||......:|:.:.:..|         |
  Rat   713 QSLPAELENMHQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMAGNCMETLRLQALRRMPHIKHVDL 777

  Fly   504 LYSVLPKSVANE---LRHQRPV---PPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKM--- 559
            ..::|.|.:.:|   |:|...:   ..|..|...::|:.|...  :|..|       ::|.:
  Rat   778 RLNILRKLITDEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVL--HCERN-------QLVTLNIC 833

  Fly   560 ---LNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAK---CMARVALDMMDMAK 618
               |..||...:.|.    .|:||.|    ..|::...:..:|.:...   |.:| .|:::|:..
  Rat   834 GYFLKALYASSNELV----QLDVYPV----PNYLSYMDVSRNCLESVPEWVCESR-KLEVLDIGH 889

  Fly   619 NVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGV-------------PG 670
            | ::...|.::.......:::.|  .||:.|         |..|.|.|.|             |.
  Rat   890 N-QICELPARLFCNSSLRKLLAG--HNRLAR---------LPERLERTSVEVLDVQHNQIIELPP 942

  Fly   671 RINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSIL 722
            .:.:..::.|.|..:.|:     ||...|..            |:..|||||
  Rat   943 NLLMKADSLRFLNASANK-----LETLPPAT------------LSEETSSIL 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	15/52 (29%)
		HNOBA	326..516	CDD:285003	49/233 (21%)
		CYCc	496..688	CDD:214485	42/228 (18%)
		Guanylate_cyc	522..714	CDD:278633	39/216 (18%)
Phlpp1	XP_038946976.1	Ubiquitin_like_fold	176..>224	CDD:421700
		PHA03247	<237..443	CDD:223021	18/71 (25%)
		RA_PHLPP1	<424..491	CDD:340760	10/66 (15%)
		PH_PHLPP-like	498..594	CDD:270131	22/128 (17%)
		PLN00113	602..>1109	CDD:215061	88/431 (20%)
		leucine-rich repeat	604..624	CDD:275380	7/27 (26%)
		leucine-rich repeat	625..655	CDD:275380	8/29 (28%)
		leucine-rich repeat	679..701	CDD:275380	1/21 (5%)
		leucine-rich repeat	702..724	CDD:275380	3/21 (14%)
		leucine-rich repeat	725..771	CDD:275380	12/45 (27%)
		leucine-rich repeat	772..795	CDD:275380	5/22 (23%)
		leucine-rich repeat	796..816	CDD:275380	3/19 (16%)
		leucine-rich repeat	817..858	CDD:275380	12/57 (21%)
		leucine-rich repeat	859..881	CDD:275380	3/22 (14%)
		leucine-rich repeat	882..904	CDD:275380	4/22 (18%)
		leucine-rich repeat	905..926	CDD:275380	7/31 (23%)
		leucine-rich repeat	927..950	CDD:275380	2/22 (9%)
		leucine-rich repeat	951..974	CDD:275380	7/39 (18%)
		leucine-rich repeat	977..1000	CDD:275380	1/1 (100%)
		leucine-rich repeat	1001..1024	CDD:275380
		leucine-rich repeat	1067..1112	CDD:275380
		PP2Cc	1151..1403	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900