DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and adcy3a

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	868	Identity:	187/868 - (21%)
Similarity:	324/868 - (37%)	Gaps:	229/868 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ELLVL----KHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDE----ITYNLIGAAVEILNIPADDI 66
            |.|:|    ||..:|:.:.:||:|......||....:|..|    :..:::|......:..|.::
Zfish   276 ERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADIVGFTQLSSSCSAQEL 340

  Fly    67 LELFGKTFFEFCQDSGYDKI--------LQVLGATPRDFLQNLDALHDHLG-TLYPGM---RAPS 119
            ::|..:.|..|      ||:        :::||..........|...||.. ::..|:   .|.|
Zfish   341 VKLLNELFARF------DKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAIS 399

  Fly   120 F--RCTEKDGELLLHYYSER-------------------------------PGLEHIVIGIVKAV 151
            :  ..|:.|.::.:..:|..                               ||..||....::.
Zfish   400 YVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLEC- 463

  Fly   152 ASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNN 216
               |||   |.|:....|....|..|||.|                  ...:|:.|.....:
Zfish   464 ---LHG---EFDVEPGNGGDRCEYLKERGI------------------ETYLVVLPKGPVGK--- 501

  Fly   217 HNGSNGSNNNGMANNGNT---VNVNNNNDGQQIASET-----------------DPSIALSTCPI 261
             ||.||...:..::|||:   :|....|.....|..|                 :|...|....:
Zfish   502 -NGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRDL 565

  Fly   262 AQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFL---------IREINVAAKSQVDAKKDEVPD 317
            |:...|.. :.||:..:||....  :|| :.||.|         :|..:...:::...:| |...
Zfish   566 AERVIDAQ-ENEQELNKLLNEAL--LER-ETVQALKGKYTNRLSLRFTDPELETRFSVEK-EKQS 625

  Fly   318 DMEFLCEA----------PLISP-------------------------ATFCKVFP-----FHLM 342
            ...|.|..          .||.|                         |.|.:|||     |...
Zfish   626 GAAFSCSCVVLLFTAVMEALIDPWLVANYVTLAVGEVLLLILTICSLAAIFPRVFPKRLVSFSTW 690

  Fly   343 FDR-----------QMKIVQAGKAVSRVIPRVAE----ENCSLIEVVEAIRPHLQ----LNFENI 388
            .|.           .:.||.....|..:..|..:    |:.::..||.|||...:    .:|..:
Zfish   691 IDHTRWARNTWAMAAIFIVTLADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKYYSFIAV 755

  Fly   389 LSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTK-KGLYISD 452
            |:.|.|..::|.          ...::|...::....|..:....:....:|.|||: |...::.
Zfish   756 LALIATTMLVQV----------SHMVKLTLMLLITVATGAVNIYSWSQTFDLYDLTRFKEYRVNL 810

  Fly   453 VPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQK-------TDRLLYSVLPK 510
            ||.......::.:  ...:.|..::::|.|...|.....::..:|:|       .:.|:.::||:
Zfish   811 VPSKYTMSVMIFI--MMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPE 873

  Fly   511 SVANEL----RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALT 571
            .||...    :....:..:.||.:.:||:.|..|..:....:..:|.::.::.|||:.:.||:|.
Zfish   874 HVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLL 938

  Fly   572 DSKRNLNVYKVETVGDKYMAVSGL-PDHCEDHAKCMARVAL----------DMMDMAKNVKM--- 622
            |..:...:.|::|:|..|||.||: .|:..:...||.:..:          |:.|.|..:|:
Zfish   939 DEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLM 1003

  Fly   623 -----GSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLL 682
                 ..|...:.||::.|.|:.||||.|.|.:.::|||||:.||.|:|||.|.|.|.|:
Zfish  1004 NINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVED----- 1063

  Fly   683 CMAINQDDSFHLEYRGPVIMKGK 705
            |..|.:|..|....|||:.:|||
Zfish  1064 CYCILKDYGFRFVRRGPIFVKGK 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	39/206 (19%)
		HNOBA	326..516	CDD:285003	45/246 (18%)
		CYCc	496..688	CDD:214485	64/221 (29%)
		Guanylate_cyc	522..714	CDD:278633	65/203 (32%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831	9/27 (33%)
		CYCc	273..468	CDD:214485	38/204 (19%)
		Guanylate_cyc	310..492	CDD:278633	35/212 (17%)
		CYCc	858..1075	CDD:214485	64/221 (29%)
		Guanylate_cyc	889..1096	CDD:278633	65/203 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900