DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and adcy1b

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	358	Identity:	100/358 - (27%)
Similarity:	159/358 - (44%)	Gaps:	55/358 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   436 SVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRD-LESEKQK 499
            ||..|:.|....|:.:.|.||....||.|             .|:.|.....:..|| :|..|..
Zfish   761 SVRGLEPLLSLLLFSTAVALHSRQLDLKL-------------RLDFLWATQAEEERDGMEKVKLD 812

  Fly   500 TDRLLYSVLPKSVANELRHQRP----VPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKML 560
            ..|:|:::||..||.......|    :..:.|..|.::|:.|..|..:.......:..::.:::|
Zfish   813 NKRILFNLLPVHVAQHFLLSNPRNMDLYYQSYAQVGVLFASIPNFNDFYIELDGNNMGVECLRLL 877

  Fly   561 NELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGL--------PDHCEDHAKCMARVALDMMDMA 617
            ||:...||.|.|.:...::.|::|:|..||:..||        ......|...:|..|::|.|:.
Zfish   878 NEIIADFDELMDKECYKDIEKIKTIGSTYMSAVGLVPTIGTKAKKSTATHLSTIADFAIEMFDVL 942

  Fly   618 KNVKMGS-NPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRL 681
            ..:...| |...:.:||:.|.||.||||.|.|:|.::|||||:.||.::|||||:|.|:|:.|||
Zfish   943 DEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVPGKIQVTEDVYRL 1007

  Fly   682 LCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGGNGSLDSPLLQP 746
            |      .:::.|..||.|.:||| ..|..:||                     .|....|.::.
Zfish  1008 L------QNNYDLMCRGNVSVKGK-GQMLTYFL---------------------EGKAQDPGIRA 1044

  Fly   747 ATPTAGAATPIPVVAQRAAGHASVSRTSSAGGG 779
            ...|.|....:..:|:.::........|||..|
Zfish  1045 PHHTGGLERRVHAIARTSSTQTKAGSVSSATSG 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	23/80 (29%)
		CYCc	496..688	CDD:214485	65/204 (32%)
		Guanylate_cyc	522..714	CDD:278633	65/200 (33%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831
		CYCc	236..431	CDD:214485
		Guanylate_cyc	272..454	CDD:278633
		DUF1053	498..585	CDD:283888
		CYCc	806..1012	CDD:214485	66/211 (31%)
		Guanylate_cyc	839..1035	CDD:278633	67/223 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900