DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and adcy2a

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_692173.5	Gene:	adcy2a / 563724	ZFINID:	ZDB-GENE-061109-1	Length:	1155	Species:	Danio rerio

Alignment Length:	246	Identity:	79/246 - (32%)
Similarity:	133/246 - (54%)	Gaps:	38/246 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 LQQTFRD----------LESEKQKTDRLLYSVLPKSVANELRH---QRPVPPK------------ 525
            |:||::|          ||.||::.:|||.|:||..:|..::.   ||...||
Zfish   275 LKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFGQVENTNNFHN 339

  Fly   526 ----RYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVG 586
                |:.:|:::::.||||.: .|::..|.   ::|.|||||:..||.:  :|.| ...:::.:|
Zfish   340 LYVQRHTNVSILYADIVGFTR-LASDCSPG---ELVHMLNELFGKFDQI--AKEN-ECMRIKILG 397

  Fly   587 DKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSN-PVQITIGIHSGEVVTGVIGNRVPRY 650
            |.|..|||||:...:|||...::.|||.:..|.|:..:. .:.:.:|:|||.|:.||||.:..:|
Zfish   398 DCYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRVGVHSGNVLCGVIGLQKWQY 462

  Fly   651 CLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVI 701
            .::.:.|.|.:..|..|||||::::.||...|..|...:|. |.:.|.|.:
Zfish   463 DVWSHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDG-HGQERDPYL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	15/39 (38%)
		CYCc	496..688	CDD:214485	69/211 (33%)
		Guanylate_cyc	522..714	CDD:278633	62/197 (31%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	15/43 (35%)
		CYCc	295..498	CDD:214485	68/209 (33%)
		Guanylate_cyc	340..524	CDD:278633	60/181 (33%)
		DUF1053	554..658	CDD:283888
		CYCc	912..1120	CDD:214485
		Guanylate_cyc	942..1141	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810