DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and npr1a

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	746	Identity:	186/746 - (24%)
Similarity:	289/746 - (38%)	Gaps:	255/746 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EKIKKKA---------------MVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGK 72
            ||:.::|               :::|:|.|   |||.....|.....|::.:|   ...:||..|
Zfish   527 EKVLRRACSKLTISLRGSNYGSLLTMDGNF---QIYAKTGYYKGNITAIKYVN---KKRIELTRK 585

  Fly    73 TFFEFCQDSGYDKILQVLGATPRDFLQNL-DALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSE 136
            ..||                     |::: |..::|| |.:.|      .|.:.....:|..|..
Zfish   586 VLFE---------------------LKHMRDVQNEHL-TRFIG------ACIDPPNICILTEYCP 622

  Fly   137 RPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSA 201
            |..|:                     |:::.:|..:|...:        ..|:.|.|
Zfish   623 RGSLQ---------------------DLMESEGITLDWMFR--------YSLINDIV-------- 650

  Fly   202 TVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSF 266
                            .|....:|:.:.::||..:.|...|.:.:...||..:         :||
Zfish   651 ----------------KGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGL---------ESF 690

  Fly   267 DCDGDKEQKCLRLLKNKSDDIERYDHVQF-----LIREINVAAKSQVDAKKDEVPD--------- 317
            ..|            :..||:..:...|.     |:|..|..|   ...:|.:|..
Zfish   691 HKD------------SNLDDVHAFYARQLWTAPELLRADNPPA---CGTQKGDVYSFGIILQELA 740

  Fly   318 --DMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPH 380
              ...|..|.|.:||                          ..:|.|          |||...|:
Zfish   741 LLKGVFYLEGPCLSP--------------------------KEIIER----------VVEGRWPY 769

  Fly   381 LQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCY-------PSVM 438
            |                   |.......|.:..    ||:|         .:|:       |...
Zfish   770 L-------------------RPLLCPQSHSEEM----GQLM---------LRCWSEDVNERPDFS 802

  Fly   439 NLDDLTKK-----GLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQ 498
            .:..|.:|     |..|.|        :|:...|::      ..|||.|.::..|.:.:   ||:
Zfish   803 QIKVLLRKNNCGYGSNILD--------NLLSRMEQY------ANNLEELVEERTQAYHE---EKR 850

  Fly   499 KTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNEL 563
            |.:.|||.:||.|||.:|:....|..:.:||||:.||.||||....|.:|    .|::|.:||:|
Zfish   851 KAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAEST----PMEVVTLLNDL 911

  Fly   564 YTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP-DHCEDHAKCMARVALDMMDMAKNVKMGSNP- 626
            ||.|||:.|   |.:||||||:||.||.||||| .:.:.||:.:||::|.:::...:.::...|
Zfish   912 YTCFDAIID---NFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPN 973

  Fly   627 --VQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQD 689
              :::.||||||.|..||:|.::|||||||:|||..||.|:.|...:|:|||.|..:|    .:.
Zfish   974 LQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVL----QEF 1034

  Fly   690 DSFHLEYRGPVIMKGKPTPMDCWFLTRATSS 720
            :.|.||.||.|.||||......|.|...:|:
Zfish  1035 NCFQLELRGDVEMKGKGRMRTYWLLGEISSN 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	28/156 (18%)
		HNOBA	326..516	CDD:285003	40/201 (20%)
		CYCc	496..688	CDD:214485	88/195 (45%)
		Guanylate_cyc	522..714	CDD:278633	87/195 (45%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380
		ANF_receptor	66..421	CDD:279440
		PK_GC-A_B	540..814	CDD:270944	72/452 (16%)
		TyrKc	554..808	CDD:197581	69/432 (16%)
		HNOBA	<823..868	CDD:285003	18/53 (34%)
		CYCc	847..1032	CDD:214485	88/198 (44%)
		Guanylate_cyc	874..1060	CDD:278633	87/196 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810