DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and adcy2b

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005170095.1	Gene:	adcy2b / 557902	ZFINID:	ZDB-GENE-060503-69	Length:	1142	Species:	Danio rerio

Alignment Length:	895	Identity:	201/895 - (22%)
Similarity:	325/895 - (36%)	Gaps:	307/895 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IYDDEITYNLI------GAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLG-------AT 93
            :|.|.:.:..:      |..|.:||       ||||| |.:..:|:...:| ::||       ..
Zfish   339 LYADIVGFTRLASDCSPGELVYMLN-------ELFGK-FDQIAKDNDCMRI-KILGDCYYCVSGL 394

  Fly    94 PRDFLQNLDALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSERPGLEHI------VIGIVK--- 149
            |       |.|.||...... |........||..|......:.|.|: |.      |||:.|
Zfish   395 P-------DPLLDHAKNCVK-MGLDMCEAIEKVREATGVDINMRVGV-HSGNVLCGVIGLQKWQY 450

  Fly   150 ----------------AVASKLHGVEVEID-------IVKRKGEPIDEAEKERAI---------A 182
                            .|..::|...|.::       :.:..|:..|...||..|         |
Zfish   451 DVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEQGNGQSRDSYLKEHGIVTYLVINPKA 515

  Fly   183 RENQQLLEDAVATTTTGS---ATVVLA---PSSDAER--NNNHNGSNGSNNNGMANNGNTVNVNN 239
            .:...||..|:..|..|:   |:|.:.   .|..|.:  .|.|:..:.:|.|||.|..:.
Zfish   516 EKRSPLLLSAIRPTMYGAKMRASVRMTQYLESWGAAKPFANLHHRDSMTNENGMINTRDV----- 575

  Fly   240 NNDGQQIASETDPSIALSTCPIAQDSFDCDGDKE--------------QKCLRLLKN-------- 282
                                |:.|  ::|....|              ::.:|.:..
Zfish   576 --------------------PLGQ--YNCQQRSERTKSQKKRFEEELNERIIRTIDGINSQKQWL 618

  Fly   283 KSDDIER---YDHVQFLIRE---------------------------INVAAKSQVDAKKDEVPD 317
            ||:||:|   :.|.:.|.:|                           :.|..|:.|    .||..
Zfish   619 KSEDIQRISLFFHNKALEKEYRATTLPAFKYYVTCACLIFFCIFIVQVLVLPKTTV----LEVSF 679

  Fly   318 DMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQ 382
            .|.||..|.::     |..|..|        |:|.|||.|..:||:...:     .|...:|.::
Zfish   680 GMAFLLLALIL-----CICFAGH--------ILQWGKAASCTMPRLPSSS-----KVITNKPWIR 726

  Fly   383 LNFEN-------ILSHINTIYVLQTRQGAMSSRHEQR---------------------------- 412
            |....       :::..|..::.:.|..|.:|.:...
Zfish   727 LALTMATTALILVMAVFNMFFLGEDRMVASTSLNISNSSMDGPYGQITNSSNNKFYLPYFIYSCI 791

  Fly   413 --------FLRLKGQMMYI------PETDRILFQCYPSVMN-----------------LDDLTKK 446
                    |||:..::..|      ...:.|:.|.:.|:::                 |.||...
Zfish   792 LGLISCSVFLRINYELKMIIMLGAVVAYNIIILQTHASILDDYSMALYKTQQPDRPGVLKDLKTM 856

  Fly   447 G---LYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEML-TDKLQQTFRDLESEKQKTDRLLYSV 507
            |   |:|..|.|      |||..:.   ||..  .|:.| .:|.::...::|:.:.....||.:|
Zfish   857 GSISLFIFFVTL------LVLARQN---EYYC--RLDFLWRNKFKKECEEIETMENLNRVLLENV 910

  Fly   508 LPKSVA----------NELRHQRPVPPKRYDSVTLMFSGIVGFGQ-YCAANTDPDGAMKIVKMLN 561
            ||..||          .:|.||      .||:|.:||:.|..|.: |..::.:.:| ::.:::||
Zfish   911 LPAHVAEHFLGRNWKNEDLYHQ------SYDTVCVMFASIPDFKEFYTESDVNKEG-LECLRLLN 968

  Fly   562 ELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGL-----------PDHCEDHAKCMARVA----- 610
            |:...||.|....:...|.|::|:|..|||.:||           .|....|...|...|
Zfish   969 EIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNVTPGLEYAQYHDRQYMHIGTMVEFAFALVG 1033

  Fly   611 -LDMMDMAKNVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINV 674
             ||:::     |...|..::.:||:.|.|:.||||.:.|:|.::|||||:.||.|:|||.|:|.|
Zfish  1034 KLDVIN-----KHSFNDFRMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQV 1093

  Fly   675 SEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSILGG 724
            :|||..:|     |...:....||.:.:|||......:..|..|.|:..|
Zfish  1094 TEETNWIL-----QTLGYMCSCRGIINVKGKGDLRTFFVHTEMTQSLSQG 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	35/166 (21%)
		HNOBA	326..516	CDD:285003	49/269 (18%)
		CYCc	496..688	CDD:214485	70/219 (32%)
		Guanylate_cyc	522..714	CDD:278633	66/209 (32%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831
		CYCc	283..486	CDD:214485	35/164 (21%)
		Guanylate_cyc	328..512	CDD:278633	40/190 (21%)
		DUF1053	542..646	CDD:283888	22/130 (17%)
		CYCc	899..1106	CDD:214485	71/223 (32%)
		Guanylate_cyc	929..1128	CDD:278633	69/215 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900