DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gucy1b2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	733	Identity:	243/733 - (33%)
Similarity:	385/733 - (52%)	Gaps:	89/733 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||||:|..|:.||::.||||.||.:  :.|..::..|:..:||||.||..|:..|.::|::.::.
Zfish     1 MYGFINTCLKSLVIERFGEETWENL--RLMAGVQETFMTYEIYDDIITLRLVQEACKMLDVSSEV 63

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCTE-KDGEL 129
            :|:|||:.||.||:.||||.:|:.||....:|::||||||.:|...|..|.|||||... .||.:
Zfish    64 VLKLFGEYFFSFCKMSGYDTMLRTLGGNLVEFIENLDALHSYLALSYEAMNAPSFRVERMDDGRI 128

  Fly   130 LLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIAR--ENQQLLEDA 192
            ||||||:|.||.|||.||::|||......||.:.|:.:..|.....:||..:..  :.:::.:..
Zfish   129 LLHYYSDRKGLYHIVPGIIEAVAKDFFDSEVTMTILNQSEEDERTGKKEHVVFHMVQKEKVTKRK 193

  Fly   193 VATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALS 257
            ..|....|...:|....|.|.......:..:|                               |.
Zfish   194 AQTRQNNSEEEILEVKKDKEETMRRMKARYAN-------------------------------LQ 227

  Fly   258 TCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFL 322
            .||..:..::                            |:|  ::....|.:.::...|...:.|
Zfish   228 LCPRKRSPWE----------------------------LVR--SIVMLGQGNLRQSFTPSYPKTL 262

  Fly   323 CEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFEN 387
                .|....||..||||::||..:.:...|..:.:.:|.:......|.|....:.|.:..|.::
Zfish   263 ----WIEEQAFCNAFPFHIVFDSDLVVKHTGVNIQKFVPGLQTAGIRLDEYFTIVHPEVIFNIQS 323

  Fly   388 ILSHINTIYVLQTRQGAMSS-RHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYIS 451
            |...||:.:||:||:..:.. :..|..|:|:||||::...:.:::.|.|.:.:|.:|.::||:::
Zfish   324 IKKFINSQFVLKTRREMLPEVQQNQPTLKLRGQMMWMESLNCMIYLCSPKLRSLQELEERGLHLA 388

  Fly   452 DVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANEL 516
            |:..||..|||:||:::..||.:|:..||...::|:...|:||.||||:::|||::||..|||:|
Zfish   389 DIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELRILSRNLEIEKQKSEKLLYAMLPTHVANQL 453

  Fly   517 RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYK 581
            :..:.|....:...|::||.:|.|...||| .:|   ::||.|||.:|:.||.||...   ||||
Zfish   454 KEGKRVEAGEFKVCTILFSDVVTFTNICAA-CEP---IQIVNMLNAMYSRFDRLTSIH---NVYK 511

  Fly   582 VETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV--KMGSNPVQITIGIHSGEVVTGVIG 644
            |||:||.||.|.|:|.....||:.:|..||.|...|:.|  .:...|:||.:|:|:|.|:.||:|
Zfish   512 VETIGDAYMVVGGVPVPTNTHAERVANFALGMRIAAREVTNPITGQPIQIRVGLHTGPVLAGVVG 576

  Fly   645 NRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPM 709
            .::|||||||:|||..||.|:.|||..|:||..|:.:    |.....|.:..||.:.:|||.. |
Zfish   577 EKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSV----IKDKGIFEMAERGEIEVKGKGL-M 636

  Fly   710 DCWF----LTRATSSILG 723
            ..:|    |.::...|:|
Zfish   637 RTYFLLKNLQKSDEQIMG 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	75/162 (46%)
		HNOBA	326..516	CDD:285003	64/190 (34%)
		CYCc	496..688	CDD:214485	86/193 (45%)
		Guanylate_cyc	522..714	CDD:278633	81/197 (41%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002	75/162 (46%)
		CAF-1_p150	<166..277	CDD:288454	23/175 (13%)
		HNOBA	269..453	CDD:285003	63/183 (34%)
		CYCc	432..618	CDD:214485	86/196 (44%)
		Guanylate_cyc	459..642	CDD:278633	81/194 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59574
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	1	1.000	-	-		FOG0002715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103261
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5317
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760