Protein Alignment Gycbeta100B and Gucy1b1

DIOPT Version :10

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_059497.1
• Gene: Gucy1b1 / 54195
• MGIID: 1860604
• Length: 620
• Species: Mus musculus
• Alignment Length: 744
• Identity: 371/744 - (49%)
• Similarity: 473/744 - (63%)
• Gaps: 146/744 - (19%)

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||||||:||||||::::|.|:||.|||:|.:..|||||||.||||..||:|:.||.::||:.|.:
Mouse     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGE 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT--EKDGE 128
            ||::|||.||.|||:||||.||:|||:..|:||||||||||||.|:||||||||||||  ||...
Mouse    66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKG 130

  Fly   129 LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            |:|||||||.||:.|||||:|.||.::||.|:::.:::::.|
Mouse   131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNE----------------------- 172

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                             
Mouse   173 ----------------------------------------------------------------- 172

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFL- 322
                    :|                      ||.||||.|        .::|:::..:|::..
Mouse   173 --------EC----------------------DHTQFLIEE--------KESKEEDFYEDLDRFE 199

  Fly   323 ---CEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLN 384
               .:...|||.||||.||||::|||.:.:.|.|.|:.||:|::...||||:.|...:|||:.::
Mouse   200 ENGTQESRISPYTFCKAFPFHIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDIS 264

  Fly   385 FENILSHINTIYVLQTRQGAMS----------SRHEQRFLRLKGQMMYIPETDRILFQCYPSVMN 439
            |..|||||||::||::::|.:.          :..|...|||||||:|:||.|.|||.|.|||||
Mouse   265 FHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMN 329

  Fly   440 LDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLL 504
            |||||::|||:||:|||||.||||||.|:|..|||||:.||:|||:||.|.|.||.||:|||.||
Mouse   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLL 394

  Fly   505 YSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDA 569
            |||||.||||||||:||||.||||:||::|||||||..:|:.:...:||||||.:||:|||.||.
Mouse   395 YSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459

  Fly   570 LTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIH 634
            ||||::|..||||||||||||.|||||:.|..||:.:..:|||||::|..|::....||||||||
Mouse   460 LTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIH 524

  Fly   635 SGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGP 699
            :|||||||||.|:||||||||||||||||||||..|:|||||.|||.|....|.|..||||:|||
Mouse   525 TGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPLFHLEHRGP 589

  Fly   700 VIMKGKPTPMDCWFLTRATSSILGGTSST 728
            |.||||..||..|||:|..:    ||..|
Mouse   590 VSMKGKKEPMQVWFLSRKNT----GTEET 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:462233	106/163 (65%)
		HNOBA	326..516	CDD:462234	115/199 (58%)
		Guanylate_cyc	522..714	CDD:425528	126/191 (66%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:462233	106/163 (65%)
		HNOBA	207..406	CDD:462234	115/198 (58%)
		Guanylate_cyc	412..605	CDD:425528	127/192 (66%)