DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_059497.1	Gene:	Gucy1b1 / 54195	MGIID:	1860604	Length:	620	Species:	Mus musculus

Alignment Length:	744	Identity:	371/744 - (49%)
Similarity:	473/744 - (63%)	Gaps:	146/744 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||||||:||||||::::|.|:||.|||:|.:..|||||||.||||..||:|:.||.::||:.|.:
Mouse     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGE 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT--EKDGE 128
            ||::|||.||.|||:||||.||:|||:..|:||||||||||||.|:||||||||||||  ||...
Mouse    66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKG 130

  Fly   129 LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            |:|||||||.||:.|||||:|.||.::||.|:::.:::::.|
Mouse   131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNE----------------------- 172

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258

Mouse   173 ----------------------------------------------------------------- 172

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFL- 322
                    :|                      ||.||||.|        .::|:::..:|::..
Mouse   173 --------EC----------------------DHTQFLIEE--------KESKEEDFYEDLDRFE 199

  Fly   323 ---CEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLN 384
               .:...|||.||||.||||::|||.:.:.|.|.|:.||:|::...||||:.|...:|||:.::
Mouse   200 ENGTQESRISPYTFCKAFPFHIIFDRNLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDIS 264

  Fly   385 FENILSHINTIYVLQTRQGAMS----------SRHEQRFLRLKGQMMYIPETDRILFQCYPSVMN 439
            |..|||||||::||::::|.:.          :..|...|||||||:|:||.|.|||.|.|||||
Mouse   265 FHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMN 329

  Fly   440 LDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLL 504
            |||||::|||:||:|||||.||||||.|:|..|||||:.||:|||:||.|.|.||.||:|||.||
Mouse   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLL 394

  Fly   505 YSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDA 569
            |||||.||||||||:||||.||||:||::|||||||..:|:.:...:||||||.:||:|||.||.
Mouse   395 YSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459

  Fly   570 LTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIH 634
            ||||::|..||||||||||||.|||||:.|..||:.:..:|||||::|..|::....||||||||
Mouse   460 LTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIH 524

  Fly   635 SGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGP 699
            :|||||||||.|:||||||||||||||||||||..|:|||||.|||.|....|.|..||||:|||
Mouse   525 TGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPLFHLEHRGP 589

  Fly   700 VIMKGKPTPMDCWFLTRATSSILGGTSST 728
            |.||||..||..|||:|..:    ||..|
Mouse   590 VSMKGKKEPMQVWFLSRKNT----GTEET 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	106/163 (65%)
		HNOBA	326..516	CDD:285003	115/199 (58%)
		CYCc	496..688	CDD:214485	131/191 (69%)
		Guanylate_cyc	522..714	CDD:278633	126/191 (66%)
Gucy1b1	NP_059497.1	HNOB	2..166	CDD:311572	106/163 (65%)
		HNOBA	207..406	CDD:311573	115/198 (58%)
		Guanylate_cyc	412..605	CDD:306677	127/192 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842070
Domainoid	1	1.000	260	1.000	Domainoid score	I1969
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H664
Inparanoid	1	1.050	756	1.000	Inparanoid score	I559
Isobase	1	0.950	-	0	Normalized mean entropy	S4189
OMA	1	1.010	-	-		QHG59574
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	1	1.000	-	-		FOG0002715
OrthoInspector	1	1.000	-	-		oto95084
orthoMCL	1	0.900	-	-		OOG6_103261
Panther	1	1.100	-	-	LDO	PTHR45655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5317
SonicParanoid	1	1.000	-	-		X5522
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750