DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Gycbeta100B and Phlpp2

DIOPT Version :9

Sequence 1:NP_524603.2 Gene:Gycbeta100B / 43682 FlyBaseID:FBgn0013973 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_001102601.2 Gene:Phlpp2 / 498949 RGDID:1562857 Length:1359 Species:Rattus norvegicus


Alignment Length:627 Identity:116/627 - (18%)
Similarity:202/627 - (32%) Gaps:206/627 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 EFCQDSGYDKI-LQVLGATPRDFLQNLD-------ALHDHLGTLYPGMRAP---SFRCTEKDGEL 129
            |.|...|.:.: ||:.|    |.::.|:       .::|:|..|  |...|   ....|..|...
  Rat   111 EICAGEGRESLYLQLHG----DLVRRLEPTERPLQIVYDYLSRL--GFEDPVRIQEEATNPDLSC 169

  Fly   130 LLHYYSERP-GLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            ::.:|.|:| .::|    :.:.:.|.::.|        |||:.......||.:            
  Rat   170 MIRFYGEKPCQMDH----LDRILLSGIYNV--------RKGKTQLHKWAERLV------------ 210

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                        :...|
  Rat   211 ------------------------------------------------------------VLCGT 215

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLC 323
            |.|.....||...| ...|.|:..|.::::|..|         ..|.|...|:........|.|.
  Rat   216 CLIVSSVKDCQTGK-MHILPLVGGKIEEVKRRQH---------SLAFSSAGAQAQTYHVSFETLA 270

  Fly   324 EAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENI 388
            |                  :.|..:  ||.|.||:.|..|.....||.||.|    ||..:.:..
  Rat   271 E------------------YQRWQR--QASKVVSQRISTVDLSCYSLEEVPE----HLFYSQDIT 311

  Fly   389 LSHINTIYVLQTRQGAMSSRHEQRFLRLKG-------------QMMYIPETDRILFQC-----YP 435
            ..::...::...|.|.:.:.:  :|.:|||             .:..|.....:...|     .|
  Rat   312 YLNLRHNFMQLERPGGLDTLY--KFSQLKGLNLSHNKLGLFPVLLCEISTLTELNLSCNGFHDLP 374

  Fly   436 S----VMNLDDLTKKGLYISDVPLHDA---ARDLVLLSEKFEAEYKLTKNLEMLT--DKLQQTFR 491
            |    ::||..|...|..::.:|  |.   .:.|..|...|....::.:.||.||  ||:.....
  Rat   375 SQIGNLLNLQTLCLDGNVLTALP--DELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGN 437

  Fly   492 DLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAAN------TDP 550
            .||            :|...|...:.|.:.|..:.....|::...:.|.......:      ||.
  Rat   438 RLE------------ILNLGVLTRMNHVKHVDLRMNHLKTVIIENLEGNKHITHMDLRDNQLTDL 490

  Fly   551 DGAMKIVKMLNELYTVFDALTD------SKRNL----------NVYKVETVGDKYMAVSGLPDHC 599
            |  :..:..|.:|:...:.|.:      |.|||          |||.|.::.........|.:..
  Rat   491 D--LSSLCSLEQLHCERNQLRELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSLELSRNLLECI 553

  Fly   600 EDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIHSGEVVTG 641
            .|.| |.|: .|:::|::.|: :...|::|...:...:::.|
  Rat   554 PDWA-CEAK-KLEILDISYNL-LTEVPMRILSSLSLRKLMVG 592

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gycbeta100BNP_524603.2 HNOB 2..164 CDD:285002 21/99 (21%)
HNOBA 326..516 CDD:285003 44/216 (20%)
CYCc 496..688 CDD:214485 31/168 (18%)
Guanylate_cyc 522..714 CDD:278633 28/142 (20%)
Phlpp2NP_001102601.2 RA_PHLPP2 66..178 CDD:340761 17/72 (24%)
PH_PHLPP-like 185..279 CDD:270131 25/203 (12%)
PLN00113 284..>762 CDD:215061 68/334 (20%)
leucine-rich repeat 289..309 CDD:275380 8/23 (35%)
leucine-rich repeat 310..336 CDD:275380 3/27 (11%)
leucine-rich repeat 337..359 CDD:275380 4/21 (19%)
leucine-rich repeat 360..382 CDD:275380 3/21 (14%)
leucine-rich repeat 383..405 CDD:275380 5/23 (22%)
leucine-rich repeat 406..428 CDD:275380 6/21 (29%)
leucine-rich repeat 429..452 CDD:275380 6/34 (18%)
leucine-rich repeat 453..476 CDD:275380 3/22 (14%)
leucine-rich repeat 477..497 CDD:275380 3/21 (14%)
leucine-rich repeat 498..517 CDD:275380 3/18 (17%)
leucine-rich repeat 518..539 CDD:275380 7/20 (35%)
leucine-rich repeat 540..562 CDD:275380 5/23 (22%)
leucine-rich repeat 563..584 CDD:275380 5/21 (24%)
leucine-rich repeat 586..607 CDD:275380 1/7 (14%)
leucine-rich repeat 608..631 CDD:275380
leucine-rich repeat 632..681 CDD:275380
leucine-rich repeat 682..705 CDD:275380
leucine-rich repeat 706..728 CDD:275380
leucine-rich repeat 751..772 CDD:275380
PP2Cc 820..1069 CDD:238083
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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