Protein Alignment Gycbeta100B and GUCY2F

DIOPT Version :10

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001513.2
• Gene: GUCY2F / 2986
• HGNCID: 4691
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 116/305 - (38%)
• Similarity: 171/305 - (56%)
• Gaps: 39/305 - (12%)

  Fly   424 PETDRILFQC----------YPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKN 478
            ||..:::.||          :..:.|......||...:.:.      .::.:.|::      :.|
Human   782 PECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIID------SMLRMLEQY------SSN 834

  Fly   479 LEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQY 543
            ||   |.:::...:||.|||||::||..:||.|||..|:....|.|:.:|.|||.||.|||| ..
Human   835 LE---DLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGF-TT 895

  Fly   544 CAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPD-HCEDHAKCMA 607
            .:|.::|   :::|.:||:|||:|||:..|.   :||||||:||.||..||||. :...||..:|
Human   896 ISAMSEP---IEVVDLLNDLYTLFDAIIGSH---DVYKVETIGDAYMVASGLPKRNGSRHAAEIA 954

  Fly   608 RVALDMMDMAKNVK---MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVP 669
            .::||::......|   |...||:|.||:|||.||.||:|..:|||||||:|||..||.|:||:|
Human   955 NMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLP 1019

  Fly   670 GRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFL 714
            .||:||..|..:|   .|..:.:.:|.||...:|||.|....|.:
Human  1020 YRIHVSLSTVTIL---QNLSEGYEVELRGRTELKGKGTEETFWLI 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:462233
		HNOBA	326..516	CDD:462234	26/101 (26%)
		Guanylate_cyc	522..714	CDD:425528	89/195 (46%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF-like	54..435	CDD:380594
		Protein Kinases, catalytic domain	545..815	CDD:473864	5/32 (16%)
		HNOBA	<824..869	CDD:462234	19/53 (36%)
		CYCc	848..1040	CDD:214485	94/201 (47%)