Protein Alignment Gycbeta100B and GUCY2C

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_004954.2
• Gene: GUCY2C / 2984
• HGNCID: 4688
• Length: 1073
• Species: Homo sapiens
• Alignment Length: 897
• Identity: 214/897 - (23%)
• Similarity: 346/897 - (38%)
• Gaps: 272/897 - (30%)

  Fly    15 KHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIG---AAVEILNIPADDILELFGKTFFE 76
            |.|.:.:.:..:|..::.|.|        ..|..|.|.|   .|.:|:.|    :::||...:||
Human   230 KEFQDILMDHNRKSNVIIMCG--------GPEFLYKLKGDRAVAEDIVII----LVDLFNDQYFE 282

  Fly    77 FCQDS----GYDKILQVLGATP-----------------RDF-LQNLDA--LHDHLGTLY----P 113
               |:    .|.|.:.||..:|                 ||| |..|:.  |..|:..::    .
Human   283 ---DNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGE 344

  Fly   114 GMRAPSFRCTEK-------DGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEP 171
            .:..|.|....:       ||.:.|..:.:   ::..::.:..:|.:|.:.|.:..|....|..|
Human   345 NITTPKFAHAFRNLTFEGYDGPVTLDDWGD---VDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYP 406

  Fly   172 ID--------EAEKERAIARENQQLLEDAVATTTTGSATVVLAPS--------SDAE-RNNNHNG 219
            :|        .::....|.....|:|..|| .|.||:..::|..:        .|.| |....:.
Human   407 VDMSPTFTWKNSKLPNDITGRGPQILMIAV-FTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSH 470

  Fly   220 SNGSNNNGM-ANNGNTVNVNNNNDGQQIASETDPSIALSTCP------IAQDSFDCDGDKEQKCL 277
            ....|...: .|..|.|::..::|.::     |....|..|.      |.:|....||:..:| .
Human   471 IPPENIFPLETNETNHVSLKIDDDKRR-----DTIQRLRQCKYDKKRVILKDLKHNDGNFTEK-Q 529

  Fly   278 RLLKNKSDDIERYDHVQFL--------------------IREI---------------------- 300
            ::..||...|:.|:..:|.                    :||:
Human   530 KIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVL 594

  Fly   301 -NVA-AKSQVDAKKDEVPDDM----------------EFLCEAPLISPATFCKVFPFHLMFDRQM 347
             ::| ..|.:.:.|.||...:                :|.|.: ::.|.......|.||   ||.
Human   595 YDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNS-ILPPKKDLWTAPEHL---RQA 655

  Fly   348 KIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQR 412
            .|.|.|...|..|  :|:|                     |:....|.|.|..|     .|:|:.
Human   656 NISQKGDVYSYGI--IAQE---------------------IILRKETFYTLSCR-----DRNEKI 692

  Fly   413 FLRLK---GQMMYIP------------ETDRILFQCY-------PSVMNLDDLTKK--GLYISDV 453
            | |::   |...:.|            |...::..|:       |....::....|  ||:
Human   693 F-RVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLF---- 752

  Fly   454 PLHDAARDLVL--LSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANEL 516
              ||...:..:  |..:.:.   .::|||.|.::..|.::   :|:.:.|||.:.:||:.|...|
Human   753 --HDQKNESYMDTLIRRLQL---YSRNLEHLVEERTQLYK---AERDRADRLNFMLLPRLVVKSL 809

  Fly   517 RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYK 581
            :.:..|.|:.|:.||:.||.||||...|..:|    .|::|.|||::|..||.:.|   :.:|||
Human   810 KEKGFVEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDHIVD---HHDVYK 867

  Fly   582 VETVGDKYMAVSGLPD-HCEDHAKCMARVALDMMDMAKNVKMGS--------NPVQITIGIHSGE 637
            |||:||.||..||||. :...||..:|::||:::..     ||:        .|:.|.||:|||.
Human   868 VETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSF-----MGTFELEHLPGLPIWIRIGVHSGP 927

  Fly   638 VVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLL----CMAINQDDSFHLEYRG 698
            ...||:|.::|||||||:|||..||.|:||:|.||:||..|..:|    |       .|..|.||
Human   928 CAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTEC-------QFLYEVRG 985

  Fly   699 PVIMKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGGNGSLDSPLLQPATPT 750
            ...:||:......|.                      .|..|.....|..||
Human   986 ETYLKGRGNETTYWL----------------------TGMKDQKFNLPTPPT 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	37/186 (20%)
		HNOBA	326..516	CDD:285003	45/215 (21%)
		CYCc	496..688	CDD:214485	84/204 (41%)
		Guanylate_cyc	522..714	CDD:278633	83/204 (41%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364	41/202 (20%)
		PK_GC-C	480..750	CDD:270946	54/308 (18%)
		Pkinase_Tyr	502..745	CDD:285015	48/276 (17%)
		CYCc	788..979	CDD:214485	84/209 (40%)
		Guanylate_cyc	815..1002	CDD:278633	83/227 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810