DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gycbeta100B and GUCY1B1

DIOPT Version :9

Sequence 1:NP_524603.2 Gene:Gycbeta100B / 43682 FlyBaseID:FBgn0013973 Length:787 Species:Drosophila melanogaster
Sequence 2:XP_011530203.1 Gene:GUCY1B1 / 2983 HGNCID:4687 Length:662 Species:Homo sapiens


Alignment Length:787 Identity:372/787 - (47%)
Similarity:474/787 - (60%) Gaps:189/787 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||||||:||||||::::|.|:||.|||:|.:..|||||||.||||..||:|:.||.::||:.|.:
Human     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGE 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT--EKDGE 128
            ||::|||.||.|||:||||.||:|||:..|:||||||||||||.|:||||||||||||  ||...
Human    66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKG 130

  Fly   129 LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            |:|||||||.||:.|||||:|.||.::||.|:::.:::::.|                       
Human   131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNE----------------------- 172

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                             
Human   173 ----------------------------------------------------------------- 172

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFL- 322
                    :|                      ||.||||.|        .::|:::..:|::.. 
Human   173 --------EC----------------------DHTQFLIEE--------KESKEEDFYEDLDRFE 199

  Fly   323 ---CEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLN 384
               .:...|||.||||.||||::|||.:.:.|.|.|:.||:|::...||||:.|...:|||:.::
Human   200 ENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDIS 264

  Fly   385 FENILSHINTIYVLQTRQGAMS----------SRHEQRFLRLKGQMMYIPETDRILFQCYPSVMN 439
            |..|||||||::||::::|.:.          :..|...|||||||:|:||.|.|||.|.|||||
Human   265 FHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMN 329

  Fly   440 LDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTD--- 501
            |||||::|||:||:|||||.||||||.|:|..|||||:.||:|||:||.|.|.||.||:|||   
Human   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGC 394

  Fly   502 ----------------------------------------RLLYSVLPKSVANELRHQRPVPPKR 526
                                                    ||||||||.||||||||:||||.||
Human   395 PARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKR 459

  Fly   527 YDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMA 591
            ||:||::|||||||..:|:.:...:||||||.:||:|||.||.||||::|..||||||||||||.
Human   460 YDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMT 524

  Fly   592 VSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNT 656
            |||||:.|..||:.:..:|||||::|..|::....||||||||:|||||||||.|:|||||||||
Human   525 VSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNT 589

  Fly   657 VNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSI 721
            |||||||||||..|:|||||.|||.|....|.|..||||:||||.||||..||..|||:|..:  
Human   590 VNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNT-- 652

  Fly   722 LGGTSST 728
              ||..|
Human   653 --GTEET 657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gycbeta100BNP_524603.2 HNOB 2..164 CDD:285002 106/163 (65%)
HNOBA 326..516 CDD:285003 116/242 (48%)
CYCc 496..688 CDD:214485 132/234 (56%)
Guanylate_cyc 522..714 CDD:278633 126/191 (66%)
GUCY1B1XP_011530203.1 HNOB 2..166 CDD:311572 106/163 (65%)
HNOBA 207..449 CDD:311573 116/241 (48%)
Guanylate_cyc 455..648 CDD:306677 127/192 (66%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151947
Domainoid 1 1.000 261 1.000 Domainoid score I1975
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H664
Inparanoid 1 1.050 756 1.000 Inparanoid score I561
Isobase 1 0.950 - 0 Normalized mean entropy S4189
OMA 1 1.010 - - QHG59574
OrthoDB 1 1.010 - - D245586at33208
OrthoFinder 1 1.000 - - FOG0002715
OrthoInspector 1 1.000 - - oto91501
orthoMCL 1 0.900 - - OOG6_103261
Panther 1 1.100 - - LDO PTHR45655
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5317
SonicParanoid 1 1.000 - - X5522
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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