Protein Alignment Gycbeta100B and GUCY1B1

DIOPT Version :10

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 372/787 - (47%)
• Similarity: 474/787 - (60%)
• Gaps: 189/787 - (24%)

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||||||:||||||::::|.|:||.|||:|.:..|||||||.||||..||:|:.||.::||:.|.:
Human     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGE 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT--EKDGE 128
            ||::|||.||.|||:||||.||:|||:..|:||||||||||||.|:||||||||||||  ||...
Human    66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKG 130

  Fly   129 LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            |:|||||||.||:.|||||:|.||.::||.|:::.:::::.|
Human   131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNE----------------------- 172

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                             
Human   173 ----------------------------------------------------------------- 172

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFL- 322
                    :|                      ||.||||.|        .::|:::..:|::..
Human   173 --------EC----------------------DHTQFLIEE--------KESKEEDFYEDLDRFE 199

  Fly   323 ---CEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLN 384
               .:...|||.||||.||||::|||.:.:.|.|.|:.||:|::...||||:.|...:|||:.::
Human   200 ENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVRPHIDIS 264

  Fly   385 FENILSHINTIYVLQTRQGAMS----------SRHEQRFLRLKGQMMYIPETDRILFQCYPSVMN 439
            |..|||||||::||::::|.:.          :..|...|||||||:|:||.|.|||.|.|||||
Human   265 FHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMN 329

  Fly   440 LDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTD--- 501
            |||||::|||:||:|||||.||||||.|:|..|||||:.||:|||:||.|.|.||.||:|||
Human   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGC 394

  Fly   502 ----------------------------------------RLLYSVLPKSVANELRHQRPVPPKR 526
                                                    ||||||||.||||||||:||||.||
Human   395 PARIQAFKVQTTLMLCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKR 459

  Fly   527 YDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMA 591
            ||:||::|||||||..:|:.:...:||||||.:||:|||.||.||||::|..||||||||||||.
Human   460 YDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMT 524

  Fly   592 VSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNT 656
            |||||:.|..||:.:..:|||||::|..|::....||||||||:|||||||||.|:|||||||||
Human   525 VSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNT 589

  Fly   657 VNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSI 721
            |||||||||||..|:|||||.|||.|....|.|..||||:||||.||||..||..|||:|..:
Human   590 VNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNT-- 652

  Fly   722 LGGTSST 728
              ||..|
Human   653 --GTEET 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:462233	106/163 (65%)
		HNOBA	326..516	CDD:462234	116/242 (48%)
		Guanylate_cyc	522..714	CDD:425528	126/191 (66%)
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233	106/163 (65%)
		HNOBA	207..449	CDD:462234	116/241 (48%)
		Guanylate_cyc	455..648	CDD:425528	127/192 (66%)