DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	708	Identity:	215/708 - (30%)
Similarity:	332/708 - (46%)	Gaps:	177/708 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLY--- 112
            ::.....||.:..::|.:.||:.||..|.... :::|:.:|.|.:||....|||.:|:.|.:
Human   154 ILQCTANILGLKFEEIQKRFGEEFFNICFHEN-ERVLRAVGGTLQDFFNGFDALLEHIRTSFGKQ 217

  Fly   113 PGMRAPSFRCTE-KDGELLLHYYSERPGLEHIV----IGIVKAVASKLHGVEVEIDIVKRKGEPI 172
            ..:.:|||.|.| .:|.|:|||:..    .|||    :|::||...|::.::||::.|
Human   218 ATLESPSFLCKELPEGTLMLHYFHP----HHIVGFAMLGMIKAAGKKIYRLDVEVEQV------- 271

  Fly   173 DEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNV 237
                       .|::|..|                                    ::|.||
Human   272 -----------ANEKLCSD------------------------------------VSNPGN---- 285

  Fly   238 NNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREI-N 301
                                          |      .||                .|||:|. |
Human   286 ------------------------------C------SCL----------------TFLIKECEN 298

  Fly   302 VAAKSQVDAKKDEVPDDMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEE 366
            ......:.....:||.|:.       ||..|||:.||||||||..|.::|.|:.:.:.:.....:
Human   299 TNIMKNLPQGTSQVPADLR-------ISINTFCRAFPFHLMFDPSMSVLQLGEGLRKQLRCDTHK 356

  Fly   367 NCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILF 431
            .....:..|.:.|.:...||.:|..::|.:|::|:..|..|.::.:.:.:||||:::||::.|||
Human   357 VLKFEDCFEIVSPKVNATFERVLLRLSTPFVIRTKPEASGSENKDKVMEVKGQMIHVPESNSILF 421

  Fly   432 QCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESE 496
            ...|.|..||:|..:||::||:|:|||.||::|:.|:.:|:..|.|.::.|...|::|.:.||.|
Human   422 LGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEE 486

  Fly   497 KQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLN 561
            |:||..||||:.|..||.:|...:.|..:::|.||::||.||||...||..|    .|:::.|||
Human   487 KKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCT----PMQVISMLN 547

  Fly   562 ELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV------ 620
            ||||.||.....   |::|||||:||.|...:||......|||.:|.:||.||::::.|
Human   548 ELYTRFDHQCGF---LDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMALKMMELSEEVLTPDGR 609

  Fly   621 --------KMGSNPVQI------------------TIGIHSGEVVTGVIGNRVPRYCLFGNTVNL 659
                    .:.|.||.|                  .||||||.|:.||:|.|:||||||||.|.|
Human   610 PIQPQRSELLFSFPVSIQLVPDQHQSETDLGTEKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTL 674

  Fly   660 TSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKG---KPTPMDCWFL 714
            .|:.|:...|.|||||..||:||    .:::||....|....:..   |..|..|:||
Human   675 ASKFESGSHPRRINVSPTTYQLL----KREESFTFIPRSREELPDNFPKEIPGICYFL 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	37/120 (31%)
		HNOBA	326..516	CDD:285003	71/189 (38%)
		CYCc	496..688	CDD:214485	92/223 (41%)
		Guanylate_cyc	522..714	CDD:278633	86/226 (38%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	37/115 (32%)
		HNOBA	316..503	CDD:285003	69/193 (36%)
		CYCc	485..705	CDD:214485	94/230 (41%)
		Guanylate_cyc	514..729	CDD:278633	87/226 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820