Protein Alignment Gycbeta100B and Gucy1b1

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_036901.2
• Gene: Gucy1b1 / 25202
• RGDID: 2769
• Length: 619
• Species: Rattus norvegicus
• Alignment Length: 744
• Identity: 370/744 - (49%)
• Similarity: 472/744 - (63%)
• Gaps: 146/744 - (19%)

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||||||:||||||::::|.|:||.|||:|.:..|||||||.||||..||:|:.||.::||:.|.:
  Rat     1 MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGE 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT--EKDGE 128
            ||::|||.||.|||:||||.||:|||:..|:||||||||||||.|:||||||||||||  ||...
  Rat    66 ILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKG 130

  Fly   129 LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            |:|||||||.||:.|||||:|.||.::||.|:::.:::::.|
  Rat   131 LILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRSE----------------------- 172

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                             
  Rat   173 ----------------------------------------------------------------- 172

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFL- 322
                    :|                      ||.||||.|        .::|:::..:|::..
  Rat   173 --------EC----------------------DHTQFLIEE--------KESKEEDFYEDLDRFE 199

  Fly   323 ---CEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLN 384
               .:...|||.||||.||||::|||.:.:.|.|.|:.||:|::....|||:.|...:|||:.::
  Rat   200 ENGTQDSRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDIS 264

  Fly   385 FENILSHINTIYVLQTRQGAMS----------SRHEQRFLRLKGQMMYIPETDRILFQCYPSVMN 439
            |..|||||||::||::::|.:.          :..|...|||||||:|:||.|.|||.|.|||||
  Rat   265 FHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMN 329

  Fly   440 LDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLL 504
            |||||::|||:||:|||||.||||||.|:|..|||||:.||:|||:||.|.|.||.||:|||.||
  Rat   330 LDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLL 394

  Fly   505 YSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDA 569
            |||||.||||||||:||||.||||:||::|||||||..:|:.:...:||||||.:||:|||.||.
  Rat   395 YSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459

  Fly   570 LTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSNPVQITIGIH 634
            ||||::|..||||||||||||.|||||:.|..||:.:..:|||||::|..|::....||||||||
  Rat   460 LTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIH 524

  Fly   635 SGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGP 699
            :|||||||||.|:||||||||||||||||||||..|:|||||.|||.|....|.|..||||:|||
  Rat   525 TGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGP 589

  Fly   700 VIMKGKPTPMDCWFLTRATSSILGGTSST 728
            |.||||..||..|||:|..:    ||..|
  Rat   590 VSMKGKKEPMQVWFLSRKNT----GTEET 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	106/163 (65%)
		HNOBA	326..516	CDD:285003	114/199 (57%)
		CYCc	496..688	CDD:214485	131/191 (69%)
		Guanylate_cyc	522..714	CDD:278633	126/191 (66%)
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:285002	106/163 (65%)
		HNOBA	207..406	CDD:285003	114/198 (58%)
		CYCc	385..584	CDD:214485	134/198 (68%)
		Guanylate_cyc	412..605	CDD:278633	127/192 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345471
Domainoid	1	1.000	260	1.000	Domainoid score	I1899
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H664
Inparanoid	1	1.050	754	1.000	Inparanoid score	I538
OMA	1	1.010	-	-		QHG59574
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	1	1.000	-	-		FOG0002715
OrthoInspector	1	1.000	-	-		oto98578
orthoMCL	1	0.900	-	-		OOG6_103261
Panther	1	1.100	-	-	LDO	PTHR45655
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5522
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770