DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Phlpp2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	623	Identity:	117/623 - (18%)
Similarity:	208/623 - (33%)	Gaps:	198/623 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 EFCQDSGYDKI-LQVLGATPRDFLQNLD-------ALHDHLGTLYPGMRAP---SFRCTEKDGEL 129
            |.|...|.:.: ||:.|    |.::.|:       .::|:|..|  |...|   ....|..|...
Mouse   107 EICAGEGRESLYLQLHG----DLVRRLEPSERPLQIVYDYLSRL--GFEDPVRIQEEATNPDLSC 165

  Fly   130 LLHYYSERP-GLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAV 193
            ::.:|.|:| .::|    :.:.:.|.::.|        |||:.......||.:
Mouse   166 MIRFYGEKPCQMDH----LDRILLSGIYNV--------RKGKTQLHKWAERLV------------ 206

  Fly   194 ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALST 258
                                                                        :...|
Mouse   207 ------------------------------------------------------------VLCGT 211

  Fly   259 CPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLC 323
            |.|.....||...| ...|.|:..|.::::|..|         ..|.|...|:........|.|.
Mouse   212 CLIVSSVKDCQTGK-MHILPLVGGKIEEVKRRQH---------SLAFSSAGAQAQTYHVSFETLA 266

  Fly   324 EAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENI 388
            |                  :.|..:  ||.|.||:.:..|.....||.||.|    ||..:.:..
Mouse   267 E------------------YQRWQR--QASKVVSQRMSTVDLSCYSLEEVPE----HLFYSQDIT 307

  Fly   389 LSHINTIYVLQTRQGAMSSRHEQRFLRLKG-------------QMMYIPETDRILFQC-----YP 435
            ..::...::...|.|.:.:.|  :|.:|||             .:..|.....:...|     .|
Mouse   308 YLNLRHNFMQLERPGGLDTLH--KFSQLKGLNLSHNKLGLFPVLLCEISTLTELSLSCNGFHDLP 370

  Fly   436 S----VMNLDDLTKKGLYISDVPLHDA---ARDLVLLSEKFEAEYKLTKNLEMLT--DKLQQTFR 491
            |    ::||..|:..|..::.:|  |.   .|.|..|...|.....:.:.||.||  ||:.....
Mouse   371 SQIGKLLNLQTLSLDGNGLTALP--DELGNLRQLTSLGISFNDFRHIPEVLEKLTMLDKVAMAGN 433

  Fly   492 DLE----------SEKQKTD-RL--LYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQ- 542
            .||          |:.:..| |:  |.:|:.:::... :|...:..:......|..|.:....|
Mouse   434 RLEVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGN-KHITHMDLRDNQLTDLDLSSLCSLEQL 497

  Fly   543 YCAANTDPDGAMKIVKM----LNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHA 603
            :|..|     .::.:.:    |..||..::.||    .:|||.|.::.........|.:...|.|
Mouse   498 HCERN-----QLRELTLSGFSLRTLYASWNRLT----AVNVYPVPSLLTSLELSQNLLECVPDWA 553

  Fly   604 KCMARVALDMMDMAKNVKMGSNPVQITIGIHSGEVVTG 641
             |.|: .|:::|::.|: :...|::|...:...:::.|
Mouse   554 -CEAK-KLEILDISHNL-LTEVPMRILSSLSLRKLMVG 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	21/99 (21%)
		HNOBA	326..516	CDD:285003	48/229 (21%)
		CYCc	496..688	CDD:214485	30/154 (19%)
		Guanylate_cyc	522..714	CDD:278633	25/125 (20%)
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	25/203 (12%)
		leucine-rich repeat	285..305	CDD:275380	8/23 (35%)
		leucine-rich repeat	306..332	CDD:275380	4/27 (15%)
		LRR_RI	309..548	CDD:238064	50/252 (20%)
		LRR_8	354..412	CDD:290566	13/59 (22%)
		leucine-rich repeat	356..378	CDD:275380	3/21 (14%)
		leucine-rich repeat	379..401	CDD:275380	5/23 (22%)
		leucine-rich repeat	402..424	CDD:275380	6/21 (29%)
		LRR_8	425..483	CDD:290566	10/58 (17%)
		leucine-rich repeat	425..448	CDD:275380	4/22 (18%)
		LRR_RI	447..714	CDD:238064	31/155 (20%)
		leucine-rich repeat	449..472	CDD:275380	4/23 (17%)
		leucine-rich repeat	474..493	CDD:275380	2/18 (11%)
		leucine-rich repeat	494..513	CDD:275380	3/23 (13%)
		leucine-rich repeat	514..535	CDD:275380	9/24 (38%)
		LRR_8	536..592	CDD:290566	11/56 (20%)
		leucine-rich repeat	536..558	CDD:275380	5/23 (22%)
		leucine-rich repeat	559..581	CDD:275380	5/22 (23%)
		leucine-rich repeat	582..597	CDD:275380	1/7 (14%)
		LRR_8	604..664	CDD:290566
		leucine-rich repeat	604..627	CDD:275380
		leucine-rich repeat	628..653	CDD:275380
		leucine-rich repeat	654..677	CDD:275380
		LRR_8	676..735	CDD:290566
		leucine-rich repeat	678..701	CDD:275380
		leucine-rich repeat	702..724	CDD:275380
		leucine-rich repeat	747..768	CDD:275380
		PP2Cc	816..1065	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900