Protein Alignment Gycbeta100B and Gucy1a2

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001028494.1
• Gene: Gucy1a2 / 234889
• MGIID: 2660877
• Length: 730
• Species: Mus musculus
• Alignment Length: 677
• Identity: 211/677 - (31%)
• Similarity: 331/677 - (48%)
• Gaps: 138/677 - (20%)

  Fly    51 LIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLY--- 112
            ::.....:|.:...:|.|.||:.||:.|.|.. :::|:.:|:|.:||....|||.:|:.|.:
Mouse   152 ILQCTANVLGLQFQEIQERFGEEFFKICFDEN-ERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQ 215

  Fly   113 PGMRAPSFRCTE-KDGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAE 176
            ..:.:.||.|.| .:|.|:|||:.....:...::|::||...:::.:.||::.:
Mouse   216 ATLESSSFLCKELPEGTLMLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQI----------- 269

  Fly   177 KERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNN 241
                   ||::|..|                           |||.||
Mouse   270 -------ENEKLCFD---------------------------GSNPSN----------------- 283

  Fly   242 DGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKS 306
                                      |      .||                .|||:|......:
Mouse   284 --------------------------C------SCL----------------TFLIKECETTQIT 300

  Fly   307 QVDAK-KDEVPDDMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSL 370
            :.:.: ..:||.|:.       ||..|||:.||||||||..|.::|.|:.:.:.:..........
Mouse   301 KDNPQGTSQVPADLR-------ISINTFCRAFPFHLMFDSNMVVLQLGEGLRKQLRYDTHRALKF 358

  Fly   371 IEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYP 435
            .:..|.:.|.:...|:.:|..::|.:|::|:..|..:.:|.:.:.:||||:::||:..|||...|
Mouse   359 EDCFEIVSPMINATFDRVLLRLSTPFVIRTKPEASGTENEDKVMEIKGQMIHVPESSAILFLGSP 423

  Fly   436 SVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKT 500
            .|..||:|..:||::||:|:|||.||::|:.|:.:|:..|.|.::.|...|::|.:.||.||:||
Mouse   424 CVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLERTHQALEEEKKKT 488

  Fly   501 DRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYT 565
            ..||||:.|..||.:|...:.|..:::|.||::||.||||...||..|    .|:::.|||||||
Mouse   489 VDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFTAICAQCT----PMQVISMLNELYT 549

  Fly   566 VFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV-KMGSNPVQI 629
            .||.....   |::|||||:||.|...|||......|||.:|.:||.||::::.| ......:|:
Mouse   550 RFDHQCGL---LDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGKAIQM 611

  Fly   630 TIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHL 694
            .||||||.|:.||:|.|:||||||||.|.|.|:.|:...|.|||||..||:||    .::|||..
Mouse   612 RIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLL----KREDSFTF 672

  Fly   695 EYRGPVIMKG---KPTPMDCWFLTRAT 718
            ..|....:..   |..|..|:||...|
Mouse   673 IPRSREELPDNFPKEIPGVCYFLELRT 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	33/116 (28%)
		HNOBA	326..516	CDD:285003	70/189 (37%)
		CYCc	496..688	CDD:214485	90/192 (47%)
		Guanylate_cyc	522..714	CDD:278633	85/195 (44%)
Gucy1a2	NP_001028494.1	HNOB	<157..268	CDD:285002	33/111 (30%)
		HNOBA	314..501	CDD:285003	68/193 (35%)
		CYCc	483..672	CDD:214485	93/199 (47%)
		Guanylate_cyc	512..696	CDD:278633	85/194 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820