DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and PHLPP1

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	512	Identity:	113/512 - (22%)
Similarity:	170/512 - (33%)	Gaps:	165/512 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 VDAKKDEVPDDMEFLCEAPLISPAT-------FCKVF--------PFHLMFDRQMKIV----QAG 353
            |.:.||.:...|..|   |||....       .|..|        .:::.||...:.:    |..
Human   571 VSSVKDSLTGKMHVL---PLIGGKVEEVKKHQHCLAFSSSGPQSQTYYICFDTFTEYLRWLRQVS 632

  Fly   354 KAVSRVIPRVAEENCSLIEVVEAIRPHLQLN--FENILSHINTIYVLQT--RQ-----GAMSSRH 409
            |..|:.|..|....|||        .||..|  :...|:|:|   :.|.  ||     .|.....
Human   633 KVASQRISSVDLSCCSL--------EHLPANLFYSQDLTHLN---LKQNFLRQNPSLPAARGLNE 686

  Fly   410 EQRFLRLKG-------------QMMYIPETDRILFQC-----YPSVM----NLDDLTKKGLYISD 452
            .|||.:||.             .:..||....:...|     .|:.:    ||......|.::..
Human   687 LQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQS 751

  Fly   453 VPLH-DAARDLVLLSEKFEAEYKLTKNLEMLT--DKL-----------QQTFRDLESEKQKTDRL 503
            :|.. :..:.|..|...|.....:.:.||.||  |||           .|..|.:...|....||
Human   752 LPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRL 816

  Fly   504 LYSVLPKSVANE---LRHQRPV---PPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKM--- 559
              :|:.|.:|:|   |:|...:   ..|..|...::|:.|...  :|..|       ::|.:
Human   817 --NVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFNNIEVL--HCERN-------QLVTLDIC 870

  Fly   560 ---LNELYTVFDALTDSKRNLNVYKVETVGDKYMAVS-----GLPDH-CEDHAKCMARVALDMMD 615
               |..||...:.|.    .|:||.|... ..||.||     .:|:. ||..       .|:::|
Human   871 GYFLKALYASSNELV----QLDVYPVPNY-LSYMDVSRNRLENVPEWVCESR-------KLEVLD 923

  Fly   616 MAKNVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNT--VNLTSRTETTGV---------- 668
            :..|        ||.      |:...:..|...|..|.|:.  ..|..|.|.|.|
Human   924 IGHN--------QIC------ELPARLFCNSSLRKLLAGHNQLARLPERLERTSVEVLDVQHNQL 974

  Fly   669 ---PGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSIL 722
               |..:.:..::.|.|..:.|:     ||...|..            |:..|:|||
Human   975 LELPPNLLMKADSLRFLNASANK-----LESLPPAT------------LSEETNSIL 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	57/256 (22%)
		CYCc	496..688	CDD:214485	49/224 (22%)
		Guanylate_cyc	522..714	CDD:278633	44/221 (20%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380
		PP2Cc	1168..1420	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131	12/62 (19%)
		PH	555..636	CDD:278594	14/67 (21%)
		LRR_RI	625..929	CDD:238064	77/345 (22%)
		LRR_8	638..703	CDD:290566	20/75 (27%)
		LRR 1	638..659		8/28 (29%)
		leucine-rich repeat	641..661	CDD:275380	7/27 (26%)
		LRR 2	661..682		6/23 (26%)
		leucine-rich repeat	662..692	CDD:275380	10/32 (31%)
		LRR 3	692..712		2/19 (11%)
		leucine-rich repeat	693..738	CDD:275380	6/44 (14%)
		LRR_8	714..770	CDD:290566	9/55 (16%)
		LRR 4	715..736		2/20 (10%)
		LRR 5	738..760		4/21 (19%)
		leucine-rich repeat	739..761	CDD:275380	3/21 (14%)
		LRR 6	761..783		5/21 (24%)
		leucine-rich repeat	762..784	CDD:275380	6/21 (29%)
		LRR 7	784..804		4/19 (21%)
		leucine-rich repeat	785..808	CDD:275380	5/22 (23%)
		LRR 8	808..831		7/24 (29%)
		leucine-rich repeat	810..832	CDD:275380	8/23 (35%)
		LRR_RI	814..1074	CDD:238064	57/255 (22%)
		LRR 9	832..853		4/20 (20%)
		leucine-rich repeat	833..853	CDD:275380	3/19 (16%)
		leucine-rich repeat	854..895	CDD:275380	12/53 (23%)
		LRR 10	873..894		8/24 (33%)
		LRR 11	895..916		6/21 (29%)
		leucine-rich repeat	896..918	CDD:275380	7/28 (25%)
		LRR 12	918..939		6/34 (18%)
		leucine-rich repeat	919..941	CDD:275380	7/35 (20%)
		LRR 13	941..962		6/20 (30%)
		leucine-rich repeat	942..963	CDD:275380	6/20 (30%)
		LRR_8	962..1024	CDD:290566	14/70 (20%)
		LRR 14	963..984		2/20 (10%)
		leucine-rich repeat	964..987	CDD:275380	2/22 (9%)
		LRR 15	987..1008		7/37 (19%)
		leucine-rich repeat	988..1011	CDD:275380	7/39 (18%)
		LRR 16	1013..1033		2/2 (100%)
		LRR_8	1014..1072	CDD:290566	1/1 (100%)
		leucine-rich repeat	1014..1037	CDD:275380	1/1 (100%)
		LRR 17	1037..1058
		leucine-rich repeat	1038..1061	CDD:275380
		LRR 18	1061..1082
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900