DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Npr2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_776149.1	Gene:	Npr2 / 230103	MGIID:	97372	Length:	1047	Species:	Mus musculus

Alignment Length:	358	Identity:	126/358 - (35%)
Similarity:	185/358 - (51%)	Gaps:	70/358 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 EVVEAI----RPHL-------QLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPE 425
            |:|:.:    ||:.       |||.|.:|        |..|..|........|.::||   :|..
Mouse   735 EIVQKVRNGQRPYFRPSIDRTQLNEELVL--------LMERCWAQDPTERPDFGQIKG---FIRR 788

  Fly   426 TDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTF 490
            .::                :.|..|.|        :|:|..|::      ..|||.|.::..|.:
Mouse   789 FNK----------------EGGTSILD--------NLLLRMEQY------ANNLEKLVEERTQAY 823

  Fly   491 RDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMK 555
            .:   ||:|.:.|||.:||.|||.:|:....|..:.:||||:.||.||||....|.:|    .|:
Mouse   824 LE---EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAEST----PMQ 881

  Fly   556 IVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPD-HCEDHAKCMARVALDMMDMAKN 619
            :|.:||:|||.|||:.|   |.:||||||:||.||.|||||. :.:.||..:||:||.::|...:
Mouse   882 VVTLLNDLYTCFDAIID---NFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSS 943

  Fly   620 VKMGSNP---VQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRL 681
            .::...|   :::.||:|:|.|..||:|.::|||||||:|||..||.|:.|...:|:||..|..
Mouse   944 FRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKD- 1007

  Fly   682 LCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFL 714
               |:::...|.||.||.|.||||......|.|
Mouse  1008 ---ALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	38/154 (25%)
		CYCc	496..688	CDD:214485	87/195 (45%)
		Guanylate_cyc	522..714	CDD:278633	86/195 (44%)
Npr2	NP_776149.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944	16/83 (19%)
		HNOBA	<798..846	CDD:369471	20/64 (31%)
		CYCc	825..1009	CDD:214485	86/197 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810