DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Adcy5

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	792	Identity:	201/792 - (25%)
Similarity:	312/792 - (39%)	Gaps:	229/792 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 CQDSGYDKI------LQVLGATPRDFLQNLD---ALHD---HLGTLYPGMRAPSFRCTEKDGELL 130
            |.:.|.|.|      .:|.|.       |::   .:|.   |.|.|  |:|...|.....|..|.
Mouse   538 CVEMGMDMIEAISLVREVTGV-------NVNMRVGIHSGRVHCGVL--GLRKWQFDVWSNDVTLA 593

  Fly   131 LHYYS-ERPGLEHIVIGIVKAVASKLHG---VE---------------VEIDIV-----KRKGEP 171
            .|..: .:.|..|    |.||..:.|:|   ||               :|..::     |||
Mouse   594 NHMEAGGKAGRIH----ITKATLNYLNGDYEVEPGCGGDRNAYLKEHSIETFLILSCTQKRK--- 651

  Fly   172 IDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERN-NNHNGSNGSNNNGMANNGNTV 235
                |::..||:.|:|      .|.:.|..    .|...|||. .||.|            ||.|
Mouse   652 ----EEKAMIAKMNRQ------RTNSIGHN----PPHWGAERPFYNHLG------------GNQV 690

  Fly   236 NVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHV-QFLI-- 297
            :......|.:...:.:          ||:|.:.:.:.::...|.:..:|.|..|.:|| :||:
Mouse   691 SKEMKRMGFEDPKDKN----------AQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTF 745

  Fly   298 REINVAAK--SQVDAKKDE-------------------VPDDMEFL-----CEAPL-----ISPA 331
            ||.::..|  .|||.:...                   ||..:..|     |...|     :|..
Mouse   746 REPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFVSVI 810

  Fly   332 TFC-KVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEV-------VEAIRPHLQLNFENI 388
            ..| |:||..|            :.:||.|.| :::|.:|:.|       :.|.......|.:|:
Mouse   811 YACVKLFPTPL------------QTLSRKIVR-SKKNSTLVGVFTITLVFLSAFVNMFMCNSKNL 862

  Fly   389 -----------LSHINTIYVLQT--------RQGAMSSRHE-------------------QRFLR 415
                       ::.:|..:|:::        .||...|...                   ..||:
Mouse   863 VGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQPNCNFPEYFTYSVLLSLLACSVFLQ 927

  Fly   416 L----KGQMMYIPETDRILFQCYPSVMNLD-----------DLTKKGLYISDVPLHDAARDL--- 462
            :    |..:|...|...:|....|.|...|           |.:..|  .|..|.|.....|
Mouse   928 ISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNG--TSQCPEHATKVALKVV 990

  Fly   463 --VLLSEKFEAEY------KLTKNLEMLTDKLQQTFRDLESEKQK--TDRLLYSVLPKSV-ANEL 516
              :::|....|.|      :.|..|:.|. |||.|....|.|:.:  ..|||:::|||.| |:.|
Mouse   991 TPIIISVFVLALYLHAQQVESTARLDFLW-KLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL 1054

  Fly   517 RHQRPVPPKRYDS---VTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLN 578
            ..:|......|.|   |.:||:.|..|.::.......:..::.:::|||:...||.:....|...
Mouse  1055 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQ 1119

  Fly   579 VYKVETVGDKYMAVSGLPDHCED-----HAKCMARVALDMMDMAKNVKMGS-NPVQITIGIHSGE 637
            :.|::|:|..|||.|||.|...|     |.|.:|..|:.:||..|.:...| |..|:.||::.|.
Mouse  1120 LEKIKTIGSTYMAASGLNDSTYDKAGKTHIKAIADFAMKLMDQMKYINEHSFNNFQMKIGLNIGP 1184

  Fly   638 VVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIM 702
            ||.||||.|.|:|.::|||||:.||.::||||.||.|:.:.|::|..     :::.||.||.|.:
Mouse  1185 VVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAA-----NTYQLECRGVVKV 1244

  Fly   703 KGKPTPMDCWFL 714
            |||...| .:||
Mouse  1245 KGKGEMM-TYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	27/116 (23%)
		HNOBA	326..516	CDD:285003	57/269 (21%)
		CYCc	496..688	CDD:214485	73/203 (36%)
		Guanylate_cyc	522..714	CDD:278633	71/200 (36%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	24/94 (26%)
		Guanylate_cyc	461..622	CDD:278633	24/96 (25%)
		DUF1053	669..761	CDD:283888	29/117 (25%)
		CYCc	1037..1238	CDD:214485	73/205 (36%)
		Guanylate_cyc	1063..1257	CDD:278633	73/199 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810