DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Adcy2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	248	Identity:	81/248 - (32%)
Similarity:	131/248 - (52%)	Gaps:	42/248 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 LQQTFRD----------LESEKQKTDRLLYSVLPKSVANELRH---QRPVPP------------- 524
            ||||:||          ||.||::.:|||.|:||..:|.|::.   ||...|
Mouse   220 LQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHN 284

  Fly   525 ---KRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVG 586
               ||:.:|:::::.||||.: .|::..|.   ::|.|||||:..||.:  :|.| ...:::.:|
Mouse   285 LYVKRHTNVSILYADIVGFTR-LASDCSPG---ELVHMLNELFGKFDQI--AKEN-ECMRIKILG 342

  Fly   587 DKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSN-PVQITIGIHSGEVVTGVIGNRVPRY 650
            |.|..|||||....:|||...::.|||.:..|.|:..:. .:.:.:|:|||.|:.||||.:..:|
Mouse   343 DCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQY 407

  Fly   651 CLFGNTVNLTSRTETTGVPGRINVSEETYRLL--CMAINQDDSFHLEYRGPVI 701
            .::.:.|.|.:..|..|||||:::|..|...|  ...:.:.|.   |.|.|.:
Mouse   408 DVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDG---EIRDPYL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	17/39 (44%)
		CYCc	496..688	CDD:214485	69/213 (32%)
		Guanylate_cyc	522..714	CDD:278633	61/199 (31%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	18/43 (42%)
		CYCc	240..443	CDD:214485	69/209 (33%)
		Guanylate_cyc	285..469	CDD:278633	60/183 (33%)
		DUF1053	499..603	CDD:283888
		CYCc	852..1060	CDD:214485
		Guanylate_cyc	882..1081	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810