DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and ADCY4

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	385	Identity:	105/385 - (27%)
Similarity:	179/385 - (46%)	Gaps:	77/385 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   439 NLDDLTKKGLYISDVPLHD---------AARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRD-- 492
            :|..|...|||:...|  |         ||..::.|.......|    :..::...|:.|||:
Human   149 SLSHLLVLGLYLGPQP--DSRPALLPQLAANAVLFLCGNVAGVY----HKALMERALRATFREAL 207

  Fly   493 --------LESEKQKTDRLLYSVLPKSVANELRHQ-----------RP--------VPPKRYDSV 530
                    |::||:..:.||.|:||..:|.|::.:           ||        :..||:..|
Human   208 SSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGV 272

  Fly   531 TLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGL 595
            :::::.||||.: .|:...|   .::|.|||||:..||.:.   :.....:::.:||.|..||||
Human   273 SVLYADIVGFTR-LASECSP---KELVLMLNELFGKFDQIA---KEHECMRIKILGDCYYCVSGL 330

  Fly   596 PDHCEDHAKCMARVALDMMDMAKNVKMGSN-PVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNL 659
            |....|||....|:.|||....:.::..:. .:.:.:|:|||.|:.||||.:..:|.::.:.|.|
Human   331 PLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTL 395

  Fly   660 TSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMK-GKPTPMDCWFLT---RATSS 720
            .:..|..|||||::::..|..||..|...:|: .:|:|.|.:.: |:||     :|.   ||..
Human   396 ANHMEAGGVPGRVHITGATLALLAGAYAVEDA-GMEHRDPYLRELGEPT-----YLVIDPRAEE- 453

  Fly   721 ILGGTSSTGGSGGGGNGSLDSPLLQPA------TPTAGAATPIPVVAQRAAGHASVSRTS 774
                 ....|:.||...||:...::|:      ..:.|||.|.   |..:.|.:.||.::
Human   454 -----EDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPF---AHLSHGDSPVSTST 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	24/95 (25%)
		CYCc	496..688	CDD:214485	65/211 (31%)
		Guanylate_cyc	522..714	CDD:278633	61/193 (32%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831	25/102 (25%)
		CYCc	219..422	CDD:214485	64/209 (31%)
		Guanylate_cyc	264..418	CDD:278633	51/160 (32%)
		DUF1053	479..583	CDD:283888	8/30 (27%)
		CYCc	827..1042	CDD:214485
		Guanylate_cyc	864..1063	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810