DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-37

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_500171.2	Gene:	gcy-37 / 191658	WormBaseID:	WBGene00001557	Length:	708	Species:	Caenorhabditis elegans

Alignment Length:	695	Identity:	185/695 - (26%)
Similarity:	326/695 - (46%)	Gaps:	142/695 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            |.|:.:..:..|:|:.:|.|:.|:|.:||....:.:|.::..|||..|..:...|..:|.:..||
Worm     1 MIGWTHVCVSALILRKYGPEVLEEILRKAGYQEDIKFDIQCYYDDTETMRIFRVAATVLGLSVDD 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTL--YPGMRAPSFRCTEKDGE 128
            :.|::|:.......::|:.|:|..:....::||.||:::|..:..:  ...|:.|:|:| |..||
Worm    66 MWEMYGEFLITHACETGWQKMLFCMANNLQEFLDNLNSMHYFIDQIAFKSEMKGPTFQC-EPFGE 129

  Fly   129 --LLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLED 191
              |.|||:|.|.||..||.|:|:..|..|..::|::.:::|..|            |....::|.
Worm   130 SGLKLHYFSFRQGLFPIVKGLVRKTARTLFEMDVKVCMLERNQE------------RRKSGMVEH 182

  Fly   192 AVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIAL 256
            .:.:               .|.::||.  .|........|..|             :|..||..|
Worm   183 VIFS---------------VEPDDNHR--KGKRLFHKFRNTKT-------------TENAPSFTL 217

  Fly   257 STCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEF 321
            |:..:..             ||..||
Worm   218 SSTILVG-------------LRDFKN--------------------------------------- 230

  Fly   322 LCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRP-HLQLNF 385
                          :||:|:.|::||.|...|..:.|......::...:.::::.::| .:||.:
Worm   231 --------------IFPYHVCFNKQMIIEHIGIYLLREYGLENKKTLKVSDLMQLVQPSDIQLTY 281

  Fly   386 ENILSHINTIYVLQTRQGAMSSRHE---------QRFLRLKGQMMYIPETDRILFQCYPSVMNLD 441
            :|:||::||:::.|.:.  .|.|:|         |:.|.|||:||.|.:.:.|:|.|.|.|..:.
Worm   282 KNVLSYLNTLFIFQLKH--HSKRNEVQEGSSEAFQQPLVLKGEMMPINDGNSIIFICSPHVTTVR 344

  Fly   442 DLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYS 506
            |:....|||||:|:|||.||||:|::....:.:|.|.||....|:::...:||.:|.:|||||:.
Worm   345 DILNLKLYISDMPMHDATRDLVMLNQSRICQMELNKKLEETMKKMKKMTEELEVKKSQTDRLLFE 409

  Fly   507 VLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALT 571
            .:|..:|..||..:.||.:.:...:::|:.|..|.. .:.|..|   .:|:.::.:|:..||.:.
Worm   410 FVPPVIAEALRAAKTVPAQEFSDCSVIFTDIPDFFT-ISVNCSP---TEIITVVTDLFHRFDRII 470

  Fly   572 DSKRNLNVYKVETVGDKYMAVSGLPD----HCEDHAKCMARVALDMMDMAKNVKMG--SNPVQIT 630
            :..:.   |||.::.|.|:.|.|:|:    ||||    ...:||.::..||.|.:.  ...|::.
Worm   471 EKHKG---YKVLSLMDSYLIVGGVPNANQYHCED----SLNLALGLLFEAKQVVVPKLERSVRLR 528

  Fly   631 IGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVS 675
            ||:|.|.||.|::..:.||:|:.|||||:|....:...||::.||
Worm   529 IGVHCGPVVAGIVSQQKPRFCVLGNTVNVTKSICSHSSPGKVLVS 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	50/165 (30%)
		HNOBA	326..516	CDD:285003	64/199 (32%)
		CYCc	496..688	CDD:214485	59/186 (32%)
		Guanylate_cyc	522..714	CDD:278633	49/160 (31%)
gcy-37	NP_500171.2	HNOB	3..165	CDD:285002	50/162 (31%)
		HNOBA	223..419	CDD:285003	68/263 (26%)
		CYCc	400..577	CDD:214485	59/185 (32%)
		Nucleotidyl_cyc_III	425..609	CDD:299850	49/160 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I3950
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H664
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59574
OrthoDB	1	1.010	-	-		D245586at33208
OrthoFinder	1	1.000	-	-		FOG0002715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103261
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.730