DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-23

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	841	Identity:	200/841 - (23%)
Similarity:	332/841 - (39%)	Gaps:	214/841 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYGFVN-------YALELLVLKH---------FGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITY 49
            :||:::       |||.:....:         .|:|:|..:::                   ||:
Worm   314 IYGYIHLYDALRLYALAVRATMNETGNENSYLNGKEVWNHMRR-------------------ITF 359

  Fly    50 -NLI-GAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGT-- 110
             .|: .|.|....:..|||.|. ...:..|......|.:.:|....| ..|.|.|......|.
Worm   360 PGLVSNAGVTSGTVMMDDIAER-APVYAAFYVPPNSDTVRKVCELEP-VMLTNCDGTKTGNGCYE 422

  Fly   111 ---------LYPGMRAPSFRCTEKDGEL-----LLHYYSERPGLEHIVIG--IVKAVASKLHGVE 159
                     .:|.:          ||.|     ...:.:|:.....::||  ||..:...:
Worm   423 LQVTDLSTGFWPSI----------DGSLPADEPACGFRNEKCDYTTLIIGGCIVLLIILLI---- 473

  Fly   160 VEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNN------HN 218
            :...|:.|..|       .||:|....::..|...|........:|:..|...:.:|      |:
Worm   474 ICFFILSRVCE-------NRALANTPWRIYRDDFRTIQENEMKSMLSIGSSKTKMSNMSMFVKHH 531

  Fly   219 GSNGSNNNGMAN--NGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQK------ 275
            ...|:|.:...:  ......|.|..| .|:.::...::..:..|....||:   :||:.
Worm   532 AVVGTNTHASFHLYPQRRPIVFNRQD-LQLLNQMKQAVHDNLNPFLGMSFN---EKEEMVVLWKF 592

  Fly   276 CLR-----LLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISPATFCK 335
            |.|     ::.|:...::...|..| ||:|.:.               :|:|..:.:   .....
Worm   593 CSRGTIQDMIYNQEVSLDSKFHGAF-IRDITLG---------------LEYLHSSII---GYHGS 638

  Fly   336 VFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIR------------------PHLQ 382
            :.|:..:.||...|......::..:.|  .|...||. .|.::                  |.:.
Worm   639 LTPWSCLIDRNWMIKLTDYGIANPLER--WEKLGLIS-TETLKEGDDKSGSAQKTSLLYQPPEML 700

  Fly   383 LNFE-NILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYP-----SVMNLD 441
            .|.| |....::..:|.|::     :|.:...:...|.:|:     .|||:..|     :|..:.
Worm   701 KNKESNRTRRMDQSWVKQSQ-----ARRQMGDIYAFGMVMH-----EILFRALPFPNGTNVSEVM 755

  Fly   442 DLTKKGLYISDVPLHDAAR---DLVLL-----SEKFEAEYKL------TKN-------------- 478
            |..:.|.......:||..:   |||.|     :|..|....:      |:|
Worm   756 DYIRDGTKTFRPTVHDRTQIHPDLVALLLDCWNENPEVRPSIRRVRLNTENYLKVKGSLVDQMMR 820

  Fly   479 -LEMLTDKLQQTFRD----LESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIV 538
             :|...:.|::...:    ||....:.|:||..:|||.|||||:..|.||.|.:|..|:|||.||
Worm   821 MMEQYANNLEKLVAERTGMLEEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIV 885

  Fly   539 GFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP-DHCEDH 602
            ||...|:::|    .:::|.|||.:|:.||   |:......|||||:||.||.|||:| ::..:|
Worm   886 GFTTICSSST----PLEVVSMLNSIYSKFD---DAINKHGSYKVETIGDAYMIVSGIPEENGNEH 943

  Fly   603 AKCMARVALDMMDMAK--------NVKMGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNL 659
            .:.:...||::|.:.|        |||:     :|.:|||:|.|..||:|...|||||||:|||:
Worm   944 IRNICNTALELMLLLKTYEIPHRRNVKL-----RIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNV 1003

  Fly   660 TSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSS 720
            .||.|:|..|.:|.:|:|. |..|  :.....|.:..||.|..|||......|.|.:.:.|
Worm  1004 ASRMESTSEPEKIQMSQEA-RDFC--VRYYSEFQITLRGTVEAKGKGPVTSYWLLGKQSES 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	34/197 (17%)
		HNOBA	326..516	CDD:285003	48/246 (20%)
		CYCc	496..688	CDD:214485	84/200 (42%)
		Guanylate_cyc	522..714	CDD:278633	80/200 (40%)
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141	21/113 (19%)
		ANF_receptor	38..385	CDD:279440	17/90 (19%)
		PK_GC	509..806	CDD:270894	59/332 (18%)
		HNOBA	<817..863	CDD:285003	13/45 (29%)
		CYCc	842..1035	CDD:214485	85/207 (41%)
		Guanylate_cyc	869..1056	CDD:278633	80/201 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810