DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-19

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001348702.1	Gene:	gcy-19 / 191650	WormBaseID:	WBGene00001544	Length:	1187	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	148/532 - (27%)
Similarity:	236/532 - (44%)	Gaps:	111/532 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 RYDHVQFL-----IREINVAAKSQVDAK----------KDEVPDDMEFLCEAPLISPATFCKVFP 338
            :|.|..||     :|...|.......||          :::.|.....|..||.:...|   :.|
Worm   687 KYLHNSFLHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEKKPMKRRQLWMAPEVIRGT---LLP 748

  Fly   339 FHLMFDRQMKIVQAGKAVSRVIPR-----VAEENCSLIEVVEAIR------PHLQLNFENILSHI 392
            ..:  ::...|.......|.|:.|     :||...::.|:|..|:      |..:|:.:.:..:.
Worm   749 HQI--EKSADIYSLAVIASEVLTRKEAWNMAERKDTVDEIVYRIKKGGPNAPRPELDMDGVEINH 811

  Fly   393 NTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNL--DDLTKKGLYISDVPL 455
            |.:.::   :...|.....|           |..|.|   |     ||  :.:.|||
Worm   812 NLLILI---RDCWSEEPADR-----------PSADVI---C-----NLLKNMMPKKG-------- 846

  Fly   456 HDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQR 520
                   .|:...|......|.|||:   :::...::|.:||:|.|.||..:|||.||..|:..:
Worm   847 -------NLMDHVFNILEDYTTNLEV---EVEDRTKELTAEKKKADVLLGRMLPKQVAERLKQGQ 901

  Fly   521 PVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETV 585
            .|.|:.:||||:.||.:|.|.| .||...|   .::|.:||:||:.|||:.:..   ..||||::
Worm   902 TVEPEGFDSVTVFFSDVVKFTQ-LAAKCSP---FQVVNLLNDLYSNFDAIIEEH---GCYKVESI 959

  Fly   586 GDKYMAVSGLPD-HCEDHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVTGVIGNR 646
            ||.|:.|||||. :...|.|.:..::||.|...|:.|:...|   |::.||::||..|.||:|..
Worm   960 GDGYLCVSGLPSKNGNAHIKQIVELSLDFMSYCKSFKIPHLPREKVELRIGVNSGPCVAGVVGLS 1024

  Fly   647 VPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDC 711
            :|||||||:|||..||.|:.|....|::|..:|.||..  :..:.::...||.||:|||......
Worm  1025 MPRYCLFGDTVNTASRMESNGKASHIHLSAASYTLLMK--HYPNQYNTASRGDVIIKGKGVMETF 1087

  Fly   712 WFLTRATSSILGGTSSTG---GSGGGGNGS----------------LDSPLL-----QPATPTAG 752
            |...| .:..:|.:|::|   ......|||                .:||:.     .|::||..
Worm  1088 WVFER-NNQFMGVSSNSGYQSDKKATNNGSSPESTPPSTPPMHEVKANSPVRHRKPPSPSSPTLS 1151

  Fly   753 AATPIPVVAQRA 764
            ..:..|::..:|
Worm  1152 KRSVSPIMEAKA 1163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	44/202 (22%)
		CYCc	496..688	CDD:214485	82/195 (42%)
		Guanylate_cyc	522..714	CDD:278633	78/195 (40%)
gcy-19	NP_001348702.1	PBP1_NPR_GC_like	45..467	CDD:107347
		PKc_like	571..841	CDD:328722	34/180 (19%)
		CYCc	876..1065	CDD:214485	82/197 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810