DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-15

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	692	Identity:	168/692 - (24%)
Similarity:	282/692 - (40%)	Gaps:	173/692 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 IVIGIVKAVA---------SKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLL-EDAVATTT 197
            ::||:..|.|         .:||.:...||             :.:.|.:::..|: :.::.:..
Worm   442 VLIGLAIAAAFLYKRYRYERRLHSLFFMID-------------RNQIILKKHTNLMSQQSLRSMA 493

  Fly   198 TGSATVVLAPSSDAERN---NNHNGSNGSNNNGMANNGNTVNVN-----NNNDGQQIASETD--- 251
            :...:||.|..:..:.:   .::|.::..|.:.:.|.|:|....     ....|...|||.:
Worm   494 SIHGSVVAASQTLRDSHFFIEDYNNASSINASSIFNTGSTARAGPFGPIPGFGGVTGASEDEKWH 558

  Fly   252 --PSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIE--RYDHVQ------------------ 294
              |...:             |..|.:.:.|.:....|:|  |.:.::
Worm   559 QIPDFGV-------------GLYEGRTVALKRIYRSDVEFTRSNRLEIAKLQESVNSNVIEFVGM 610

  Fly   295 -------FLIREINVAAKSQVDAKKDEVP-DD-------------MEFLCEAP------------ 326
                   |::.|:......:.....|::| ||             :|:|..:|
Worm   611 VVQSPDVFVVYELAQRGSLKDILDNDDMPLDDVFRSQMTKDIIAGLEYLHSSPVGCHGRLKSTNC 675

  Fly   327 LISPATFCKVFPFHLMFDR------QMKIVQAGKAVSRVIPRVAE-----ENCSLIEVVEAIRPH 380
            ||......::..|.|...|      |...||.||......|.:..     ..|.::.|.::
Worm   676 LIDARWMVRLSSFGLRELRGEETWQQEDDVQEGKDQLWTSPELLRWSTGLSQCGVLLVQKS---- 736

  Fly   381 LQLNFENILSHINTIYVLQTRQG-----AMSSRHEQRFLR---LKGQ------MMYIPETDRILF 431
                  ::.|....:|.|..|.|     .|..|.....::   |.|:      |..:.|:.||:.
Worm   737 ------DVYSLAIVLYELFGRLGPWGDEPMEPREIVSLVKREALAGKKPFRPDMAVLKESPRIVQ 795

  Fly   432 QCYPSVMNLDDLTKKGLYISDVPLHDAARDL--VLLSEKFEAEYKLTKNLEMLTDKLQQTF---- 490
            :...:....|.|.:..       ||...|.|  :.:..|......:...:|..||||::..
Worm   796 ETVVAAWTEDPLNRPS-------LHQIKRKLKPLTIGLKRTIMDNMVSMIEKYTDKLEKDIAERN 853

  Fly   491 RDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMK 555
            .:||:||.|::.||..:||:.||:.|:....|..:.:::.|:.||...||.:..|.:...|
Worm   854 EELEAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPID---- 914

  Fly   556 IVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP----DHCEDHAKCMARVALDMMDM 616
            ||:.||:||||||.:.|   ..:||||||:.|.||..||||    :|   ||..:|.:.|.::..
Worm   915 IVQFLNDLYTVFDRIID---QFDVYKVETIADAYMVASGLPVPNGNH---HAGEIASLGLALLKA 973

  Fly   617 AKNVKMGSNP---VQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEET 678
            .::.|:...|   |::.||::||..|.||:|.::|||||||:|||..||.|:.|:|.|||.|...
Worm   974 VESFKIRHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTA 1038

  Fly   679 YRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSS 720
            ..:|    :|...:.:|.||.|.||||...|.  :..|..:|
Worm  1039 KEIL----DQLGGYEIEERGIVEMKGKGKQMT--YFVRGENS 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	7/29 (24%)
		HNOBA	326..516	CDD:285003	50/232 (22%)
		CYCc	496..688	CDD:214485	78/198 (39%)
		Guanylate_cyc	522..714	CDD:278633	78/198 (39%)
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822
		PK_GC	553..822	CDD:270894	49/298 (16%)
		HNOBA	<831..879	CDD:400168	16/47 (34%)
		Guanylate_cyc	885..1071	CDD:306677	78/201 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810