DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-9

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_509897.3	Gene:	gcy-9 / 191645	WormBaseID:	WBGene00001536	Length:	1081	Species:	Caenorhabditis elegans

Alignment Length:	792	Identity:	193/792 - (24%)
Similarity:	317/792 - (40%)	Gaps:	193/792 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GEEIWEKIKKKAMVSMEGQFLVRQ---IYDDEITYNLIGAAVEILNIPADDILELFGKTFFEFCQ 79
            |..||.::..:..:.|.||.|:..   ......||:.|...::|       ::||..|.     .
Worm   364 GSLIWSRMTNRQFIGMTGQVLMNNKAIRVPSYATYHAINGTLKI-------VVELEAKN-----N 416

  Fly    80 DSGYDKILQVLGATPRDFLQNLDALHDHL-------------GTLYPGMRAPSFRCTEKD----- 126
            |.|..:             :|.:...:|:             |.|.|.:....|...|.|
Worm   417 DRGQCE-------------KNEEMCSEHVAHETIQYYWPSDSGKLPPAVPKCGFTGAECDYRPYF 468

  Fly   127 -GELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKER-------AIAR 183
             |..||.:......|.:.:                   .:|         :|||       .|.|
Worm   469 IGASLLAFILTVGPLSYFI-------------------YLK---------QKERLLYDMTWRIPR 505

  Fly   184 ENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGM------ANNGNTVNVNNNND 242
            |:.::||        |.:....:.:|.::.:.:.:||..|..||:      .:||..:.:...
Worm   506 ESIKMLE--------GKSKSEHSLASKSQSSGSFSGSMNSKQNGLIAAKQAVSNGVKLAIKRY-- 560

  Fly   243 GQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIR--------- 298
             ||:.:.|.|.   |...:.::...|:.|...|...:..|:.:        :|::.
Worm   561 -QQVRNITFPK---SELRLLKELKICENDNLNKFYGISFNQQN--------EFIVMWVLCSRGSL 613

  Fly   299 -------EINVAAKSQVDAKKDEVPDDMEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAV 356
                   |:.:....||...|| |...:.||..:||:.....|..   :.:.|....:.....|.
Worm   614 EDILFNDELKLGRNFQVSFAKD-VVKGLNFLHTSPLLHHGMLCLQ---NCLVDSNWTVKLTNFAT 674

  Fly   357 SRVI----------PRVAEENCSLIEVVE-----AIRPHLQLNFENILSHINTIYVLQTRQGA-- 404
            ..||          |.:..::.|..:|.:     |.:.:||...|.|...:.|..:.:..|.|
Worm   675 EAVIFEKLDHNELRPFINTDSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPEGSQSADI 739

  Fly   405 -------------MSSRHEQR--FLRLKGQMMYIPETDRILFQCYPS--------VMNLDDLTKK 446
                         :...||:.  ..:|...:....:.|:::...:||        :..|..:...
Worm   740 YALGMVLYQILFRVEPFHERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQLLSCIEAC 804

  Fly   447 GLYISDV-PLHDAARDLVLLSEKFEAEYKLT----KNLEMLTDKLQQTFRD----LESEKQKTDR 502
            .|.|.:: |.....|.:|..:.|...:..|.    |.:|..|..|:...||    ||..:::.||
Worm   805 WLEIPEMRPPIKKVRTMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQADR 869

  Fly   503 LLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVF 567
            ||.|:||||:|.:|:..:||.|:.|...|::||.|.||.:..:.:|    .:::|..||::::.|
Worm   870 LLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGFTRISSTST----PLQVVTFLNDMFSGF 930

  Fly   568 DALTDSKRNLNVYKVETVGDKYMAVSGLP-DHCEDHAKCMARVALDMMDMAKNVKMGSNP---VQ 628
            ||:....   :.|||||:||.||.|||:| ::...||:.:|.|||.|.....|.|:...|   :.
Worm   931 DAIIAKH---DAYKVETIGDAYMIVSGVPTENGNSHAQNIADVALKMRAFICNFKLAHRPEELMM 992

  Fly   629 ITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFH 693
            :.||.|||.|..||:|...|||||||:|||..||.|:|||..:|.:||..|.||.....|   |.
Worm   993 VRIGFHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVANKIQISEGAYNLLHCFFPQ---FQ 1054

  Fly   694 LEYRGPVIMKGK 705
            :..||.:.:|||
Worm  1055 MVERGKIEVKGK 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	28/167 (17%)
		HNOBA	326..516	CDD:285003	50/238 (21%)
		CYCc	496..688	CDD:214485	82/195 (42%)
		Guanylate_cyc	522..714	CDD:278633	77/188 (41%)
gcy-9	NP_509897.3	Periplasmic_Binding_Protein_Type_1	66..416	CDD:299141	14/63 (22%)
		ANF_receptor	69..404	CDD:279440	10/39 (26%)
		PKc_like	550..820	CDD:304357	48/287 (17%)
		HNOBA	<837..883	CDD:285003	18/45 (40%)
		CYCc	862..1054	CDD:214485	83/201 (41%)
		Guanylate_cyc	889..1076	CDD:278633	77/188 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810