DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-4

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	664	Identity:	163/664 - (24%)
Similarity:	280/664 - (42%)	Gaps:	172/664 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 IVIGIVKAVASK----------------LHGVEVEIDIVKRKGEPIDEAEKERAIAREN------ 185
            |::.|:..::||                :|.:::.:.:.:|..:...|:|.|.|...||
Worm   498 ILLAIIICMSSKIRNRRVEQSRLHSEWQIHAIKLRLPMHRRASKSSQESETESASETENFTSKSG 562

  Fly   186 -------------QQLLEDAVATTTTGSATVVLAPSSDAE-------RNNNHNGSN---GSNNNG 227
                         |.|..|.|.||..     .:...|.||       |..:|...|   |.:.:|
Worm   563 DTMTSEFKETYTIQYLENDLVLTTAH-----QVQELSQAEMMKFVKLRKLDHENLNKFIGLSIDG 622

  Fly   228 --------MANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQKCLRLLKNKS 284
                    |.:.|:..::                       |::.||..|   ......::::.:
Worm   623 SRFVSVWKMCSRGSLQDI-----------------------ISKGSFSMD---YFFMFCMIRDIA 661

  Fly   285 DDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISPATFCKVFPFHLMF--DRQM 347
            :.: .|.|..||....|:.:.:                |   |::.:...|:..|.|.|  |.:.
Worm   662 EGL-HYIHKSFLRHHGNLRSAT----------------C---LVNDSWQVKLADFGLQFLQDEEE 706

  Fly   348 KIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQR 412
            |..:  |.:....|.|...:.|:.::..:...:   :|..:.|.|     |..|:....||.::.
Worm   707 KPFK--KNMLWAAPEVIRGSLSIEQMDSSADIY---SFAIVASEI-----LTKREAWDLSRRKEG 761

  Fly   413 FLRLK------GQMMYIP------ETDRILF----QCY-------PSVMN----LDDLTKKGLYI 450
            :..:|      ||.:..|      |.::.|.    .|:       ||..|    |.|:|..
Worm   762 YEEIKYAVKKGGQFVLRPDLHIDIEVNQTLLALVKDCWCENPEERPSAENVCKVLFDMTPN---- 822

  Fly   451 SDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANE 515
                ..|...|.|     |....:.|.:||:   ::.:..::|..||:|:|.||..:|||.||..
Worm   823 ----TEDNLMDHV-----FSMLEEYTSSLEV---EVGERTKELTLEKKKSDILLGRMLPKQVAER 875

  Fly   516 LRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVY 580
            |:..:.|.|:.:|.||:.||.:|.|.. .|:...|   .::|.:||::::.||::.:..   :||
Worm   876 LKAGQAVEPESFDLVTVFFSDLVKFTD-LASKCSP---FQVVNLLNDVFSNFDSIIEKH---DVY 933

  Fly   581 KVETVGDKYMAVSGLPD-HCEDHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVTG 641
            |||::||.::.|||||: :..:|.:.:..::|..|:..:|.::...|   |::.:||:||..|.|
Worm   934 KVESIGDGFLCVSGLPNRNGMEHIRQIVGMSLCFMEFCRNFRIPHLPRERVELRVGINSGPCVAG 998

  Fly   642 VIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKP 706
            |:|..:|||||||:|||..||.|:.|.|..|::||..:.||  ..|....|....||.||:|||.
Worm   999 VVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLL--VNNYPYQFETNSRGEVIIKGKG 1061

  Fly   707 TPMDCWFLTRATSS 720
            .....|.|.:.:.|
Worm  1062 VMETYWLLGKMSLS 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	5/36 (14%)
		HNOBA	326..516	CDD:285003	50/218 (23%)
		CYCc	496..688	CDD:214485	74/195 (38%)
		Guanylate_cyc	522..714	CDD:278633	72/195 (37%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347
		ANF_receptor	49..423	CDD:279440
		PKc_like	558..819	CDD:304357	55/321 (17%)
		HNOBA	<834..876	CDD:285003	15/44 (34%)
		CYCc	855..1047	CDD:214485	75/200 (38%)
		Guanylate_cyc	882..1070	CDD:278633	72/196 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810