Protein Alignment Gycbeta100B and phlp-2

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001337270.1
• Gene: phlp-2 / 185690
• WormBaseID: WBGene00009647
• Length: 1126
• Species: Caenorhabditis elegans
• Alignment Length: 916
• Identity: 169/916 - (18%)
• Similarity: 291/916 - (31%)
• Gaps: 332/916 - (36%)

  Fly    25 IKKKA----MVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFFEFCQDSGYDK 85
            |:||:    :.|.:||...| |..||.|                        |..:.||....|.
 Worm    20 IEKKSRFLRLYSSDGQRSTR-IECDEHT------------------------TCAQICQQFSCDV 59

  Fly    86 ILQVLG--------------ATPRDFLQNLDALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSE 136
            |...:|              |..:||.:.|....::|.|          ..|.|..|.:|. |::
 Worm    60 ITLQIGNYHFRQLKSDTSPLAILQDFCRILTMSDENLET----------ESTSKALEDILS-YTD 113

  Fly   137 RPGLEHI---VIGIVKAVASKLHGVEV-EIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTT 197
            .|...||   .:|..:..|.....::: ..::|.|||:.|...:..||:...:...|:
 Worm   114 SPAFRHIFSFFLGRPRIRAKSTLNLDILSEEVVIRKGKLIHTWQNARAVFYNSNIRLQ------- 171

  Fly   198 TGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETD----------P 252
                          .:||        .:..:......|:|:.:..|:.:..:.|          |
 Worm   172 --------------TKNN--------QDEALQIRNMKVDVHESKRGRALRLKDDDVCYLIIFQRP 214

  Fly   253 SIA---LSTCPIAQDSFDCDGDKEQKCL---RLLKNKS--------------------------- 284
            :|.   |:.....:.|...|...||..|   ::|.|::
 Worm   215 NILEAWLTRAQQVEKSNHVDASDEQLTLIPEQILNNEARVQILNLRRNSLISRPPTEKSMAPLGY 279

  Fly   285 -DDIERYDHVQFL-------------------IREINVAAK--SQVDA----------------K 311
             ||:.|...:|.:                   :|::|:::.  |.|.:                :
 Worm   280 IDDLYRVHSLQVIDLSANQILSFPIQLTLLSHLRQLNLSSNYISSVPSECSNMRRLQYLNLSNNQ 344

  Fly   312 KDEVPDDMEFL--CEAPLISPATFCKVFP--FHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIE 372
            .|.:||.:..|  .::..||...|.::.|  |||..:...   .||..:.: |.||.|.....|:
 Worm   345 LDTLPDSISELQNLQSLDISFNQFSQIPPCLFHLTLEMWR---LAGNNIEK-IDRVGEMQIQKID 405

  Fly   373 V-VEAIRPHLQLNFENIL-------SHINTIYVLQTRQGAMSSRHEQRF----LRLKGQ------ 419
            : ...:....:|:.|||.       |.|:|:::...|  .:...|.:|.    |.|.|:
 Worm   406 LRRNVLDTSFRLDIENITHLDLRDNSMISTVHLTNLR--FLKVIHCERLQLSSLHLSGESLTHVY 468

  Fly   420 ----------MMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVP----LHDAARDLVLL----- 465
                      :|.:|:..:.|...:....||.|      :|||.|    |......||.|
 Worm   469 ADHNLLDSLVVMPLPQNLQTLSLSFNHFRNLPD------WISDCPNLTFLRANNNSLVALPERIF 527

  Fly   466 -SEKFEAEYKLTKNLEMLTDKLQQT-FRDLESEKQKTDRL---LYSVLPK--------------- 510
             |:...:.:.....:|.:.|..::. ...|...|.|...|   .:|:||:
 Worm   528 YSQSLRSIFAFINEIEHIPDFGEENCLETLILYKNKLSSLPKHFFSILPRLRQLNISSNFIELLP 592

  Fly   511 -------------SVANELRHQRPVP----PKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVK 558
                         ..||....:..||    .|....:.|..:.:         |:..|.|:..::
 Worm   593 YFDGSSFCRLQILRCANNYLTENSVPVIVNMKHLKIIDLSHNRL---------NSFDDSALSSLE 648

  Fly   559 MLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPDHCEDHAKCMARV-ALDMMDMAKNVKM 622
            :|.:|            ||:..::..:.|                 |:|.: .|.::....|..:
 Worm   649 LLEDL------------NLSSNRLTRLAD-----------------CLALLPCLQVLRAHSNQLV 684

  Fly   623 ------GSNPVQITIGIHSGEVVTGVIGNRVP---RY----CLFG--NTVNLTSRTETTGVPGRI 672
                  .||.:. ||.:.|..:..|.:..:.|   |:    |..|  :|.|.....:.......|
 Worm   685 HVPEFRASNQLH-TIDVSSNNISLGTLQFKAPPNLRHFDVTCNSGDFDTENFPENAKMHSKMNTI 748

  Fly   673 NVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGGNG 737
            |:||.:..|....|....|     ||   ||.|    .|....|..::.       |...||.|.
 Worm   749 NISEGSQNLFGFQIGVSGS-----RG---MKNK----QCIRQVRVENTF-------GFIDGGSNS 794

  Fly   738 SLDSPL 743
            .:.|.:
 Worm   795 YMSSSI 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	33/160 (21%)
		HNOBA	326..516	CDD:285003	53/261 (20%)
		CYCc	496..688	CDD:214485	42/242 (17%)
		Guanylate_cyc	522..714	CDD:278633	41/211 (19%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	6/20 (30%)
		leucine-rich repeat	254..288	CDD:275380	3/33 (9%)
		PLN00113	283..>718	CDD:331614	86/485 (18%)
		leucine-rich repeat	289..311	CDD:275380	1/21 (5%)
		leucine-rich repeat	312..334	CDD:275380	4/21 (19%)
		leucine-rich repeat	335..357	CDD:275380	4/21 (19%)
		leucine-rich repeat	358..379	CDD:275380	6/20 (30%)
		leucine-rich repeat	380..440	CDD:275380	14/63 (22%)
		leucine-rich repeat	441..485	CDD:275380	8/45 (18%)
		leucine-rich repeat	486..508	CDD:275380	7/27 (26%)
		leucine-rich repeat	509..534	CDD:275380	5/24 (21%)
		leucine-rich repeat	554..577	CDD:275380	6/22 (27%)
		leucine-rich repeat	578..602	CDD:275380	0/23 (0%)
		leucine-rich repeat	603..625	CDD:275380	4/21 (19%)
		leucine-rich repeat	626..649	CDD:275380	4/31 (13%)
		leucine-rich repeat	650..672	CDD:275380	7/50 (14%)
		leucine-rich repeat	673..694	CDD:275380	3/20 (15%)
		PP2Cc	754..985	CDD:214625	15/66 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900