DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Npr1

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_032753.5	Gene:	Npr1 / 18160	MGIID:	97371	Length:	1057	Species:	Mus musculus

Alignment Length:	721	Identity:	192/721 - (26%)
Similarity:	286/721 - (39%)	Gaps:	227/721 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AMVSMEGQFLVRQIYDDEITY--NLIGAAVEILNIPADDILELFGKTFFEFCQDSGYDKILQVLG 91
            ::::.||||   |::.....|  ||:  ||:.:|...   :||..|..||
Mouse   538 SLLTTEGQF---QVFAKTAYYKGNLV--AVKRVNRKR---IELTRKVLFE--------------- 579

  Fly    92 ATPRDFLQNL-DALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSERPGLEHIVIGIVKAVASKL 155
                  |::: |..::|| |.:.|      .||:.....:|..|..|..|:.|           |
Mouse   580 ------LKHMRDVQNEHL-TRFVG------ACTDPPNICILTEYCPRGSLQDI-----------L 620

  Fly   156 HGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGS 220
            ....:.:|.:.|                  ..|..|.|      ...:.|           |||:
Mouse   621 ENESITLDWMFR------------------YSLTNDIV------KGMLFL-----------HNGA 650

  Fly   221 NGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGDKEQ----------- 274
            .||       :||..:.|...||:.:...||..:         :||. |.:.||
Mouse   651 IGS-------HGNLKSSNCVVDGRFVLKITDYGL---------ESFR-DPEPEQGHTLFAKKLWT 698

  Fly   275 --KCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISP------A 331
              :.||:....:...:..|...|.|....:|.:|.|            |..|...:||      .
Mouse   699 APELLRMASPPARGSQAGDVYSFGIILQEIALRSGV------------FYVEGLDLSPKEIIERV 751

  Fly   332 TFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIY 396
            |..:..||....|.|..:.:.|:.:.|......:|.....::..|:|...:.|..|||.:
Mouse   752 TRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDN----- 811

  Fly   397 VLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARD 461
                    :.||.||
Mouse   812 --------LLSRMEQ-------------------------------------------------- 818

  Fly   462 LVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKR 526
                         ...|||.|.::..|.:.:   ||:|.:.|||.:||.|||.:|:....|..:.
Mouse   819 -------------YANNLEELVEERTQAYLE---EKRKAEALLYQILPHSVAEQLKRGETVQAEA 867

  Fly   527 YDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMA 591
            :||||:.||.||||....|.:|    .|::|.:||:|||.|||:.|   |.:||||||:||.||.
Mouse   868 FDSVTIYFSDIVGFTALSAEST----PMQVVTLLNDLYTCFDAVID---NFDVYKVETIGDAYMV 925

  Fly   592 VSGLP-DHCEDHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVTGVIGNRVPRYCL 652
            ||||| .:.:.||:.:||:||.::|..::.::...|   :::.||||:|.|..||:|.::|||||
Mouse   926 VSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCL 990

  Fly   653 FGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRA 717
            ||:|||..||.|:.|...||::|.||..:|    .:.|.|.||.||.|.||||......|.|...
Mouse   991 FGDTVNTASRMESNGEALRIHLSSETKAVL----EEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051

  Fly   718 TSSILG 723
            ..|..|
Mouse  1052 GCSTRG 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	30/137 (22%)
		HNOBA	326..516	CDD:285003	36/195 (18%)
		CYCc	496..688	CDD:214485	89/195 (46%)
		Guanylate_cyc	522..714	CDD:278633	89/195 (46%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:107380
		ANF_receptor	50..410	CDD:279440
		PK_GC-A_B	530..803	CDD:270944	75/375 (20%)
		TyrKc	543..797	CDD:197581	73/364 (20%)
		HNOBA	<812..857	CDD:285003	20/110 (18%)
		CYCc	836..1025	CDD:214485	89/202 (44%)
		Guanylate_cyc	863..1049	CDD:278633	89/196 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810