DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-18

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_502449.2	Gene:	gcy-18 / 178237	WormBaseID:	WBGene00001543	Length:	1113	Species:	Caenorhabditis elegans

Alignment Length:	999	Identity:	225/999 - (22%)
Similarity:	355/999 - (35%)	Gaps:	360/999 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LELLVLKHFGEEIWEKIK-KKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILN--------IPAD 64
            |::.:..:.|...:|::. .:.::..||..:|:::..||.|     .|.|::|        ..|.
Worm   187 LKVAIATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENT-----DANEMMNSGQLGDLAANAR 246

  Fly    65 DILELFGKT---FFEFCQ--------DSGYDKILQVLGATPRDFLQNLDALHDHLGTLYPGMRAP 118
            .|:.||..|   ..||.|        ::.|..|:..|.:..:|              |.|.:.|
Worm   247 IIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKD--------------LTPWIGA- 296

  Fly   119 SFRCTEKDGELLL----HYYSERPGLEHIVI--------GIVKAVASKL--HGVE-VEIDIVKRK 168
                   |||:|.    ||.:.      |::        .:|.:...|:  ||:: .:||:....
Worm   297 -------DGEMLQRVKDHYANA------IIVDDVNGFDDSVVSSFVEKIEKHGMQKSDIDVTNIN 348

  Fly   169 G----------------EPIDEAEKE-----------------------RAIARENQQ------L 188
            |                :.::|.:.|                       |:.:.||:.      :
Worm   349 GYLHLFDSLKLYALAIRKVLNETDNEAYVTNGQFIWNRMRRMKFEGVVSRSSSEENKDAGAIGTV 413

  Fly   189 LEDAVATTTTGSATVVLAPSSD-AERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDP 252
            |.|.||......:...::|:.| ..:..|......||.:|:.|......:..|:.........|.
Worm   414 LMDDVADRAPIFSAFYISPNRDKVMKMVNMESELISNCDGLKNKSGCFQLKINDIKSGFWPSEDG 478

  Fly   253 SIALSTCPIAQDSFDCDGDKEQKCLRLL-------------------------KNKSDDIER--- 289
            |:.|.. ||.       |.:.|:|..||                         :||  .:|:
Worm   479 SMPLDE-PIC-------GYRGQRCSYLLEISVGSLIILLILISVVFFFLFRYCENK--QLEKMPW 533

  Fly   290 ---YDHVQFLIRE---------------------------INVAAKSQVDAKKDEVP-----DDM 319
               :|.:||:..|                           |.|...:.....|...|     :||
Worm   534 RIFHDDLQFIDEEQVKSMMSVGSVTTKLSNIQTGQKQHAIIGVNTHTTYHRYKQRRPIKFIKEDM 598

  Fly   320 EFLCEA---------PLISPA-----------TFC------------------------------ 334
            :.|.:.         |.:..|           .||
Worm   599 QLLTQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVRDITL 663

  Fly   335 --------------KVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEA--------- 376
                          .:.|:..:.||...:..:...::..:.|..::..  ||:..|
Worm   664 GLEYLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGA--IEIAAAKDSDDKSQA 726

  Fly   377 --------IRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLK-------GQMMYIPET 426
                    :.|.|..|.|.           ..|:|...|..:|..||.:       |.:||
Worm   727 SQATSIIYMAPELLKNRET-----------NKRRGMDQSWVKQSMLRRQAGDIYSFGMVMY---- 776

  Fly   427 DRILFQCYP--SVMNLDDLTKKGLYISD------------VPLHDAARDL--------------- 462
             .|||:..|  ...|:.:|..   |::|            :.||.....|
Worm   777 -EILFRSLPFRDNTNISELVD---YLADGSKTVSPEIQNQMGLHPDLNALLRDCWSENPEIRPSI 837

  Fly   463 --------VLLSEKFEAEYKLTKNLEMLTDKLQQTFRD----LESEKQKTDRLLYSVLPKSVANE 515
                    ::|..|.....::.|.:|...:.|::...:    ||....:.|:||..:||..||||
Worm   838 RRVRLNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANE 902

  Fly   516 LRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFD-ALTDSKRNLNV 579
            |:..|.|.||.|.|.|::||.||||...|:.:|    .:::|.|||.|||.|| .:|.:|.
Worm   903 LKMGRSVAPKLYSSATILFSDIVGFTTICSGST----PLEVVNMLNGLYTGFDECITRNKS---- 959

  Fly   580 YKVETVGDKYMAVSGLPDHCE-DHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHSGEVVT 640
            |||||:||.||.|||:|:..| :|::.:|..||||.......::...|   |:...|.|:|.|..
Worm   960 YKVETIGDAYMVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAA 1024

  Fly   641 GVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAIN-QDDSFHLEYRGPVIMKG 704
            ||:|...|||||||:|||::||.|:||.||.|.:|||.:    |.|. ....|....||.|.:||
Worm  1025 GVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAH----MHIRAHHPVFTTTERGEVQVKG 1085

  Fly   705 KPTPMDCWFLTRATSSILGGTSST 728
            |.|....|...|     :|..|:|
Worm  1086 KGTCRTFWLEDR-----VGDASTT 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	39/189 (21%)
		HNOBA	326..516	CDD:285003	50/309 (16%)
		CYCc	496..688	CDD:214485	88/197 (45%)
		Guanylate_cyc	522..714	CDD:278633	86/197 (44%)
gcy-18	NP_502449.2	Periplasmic_Binding_Protein_Type_1	87..448	CDD:299141	53/293 (18%)
		ANF_receptor	87..395	CDD:279440	43/240 (18%)
		PKc_like	549..846	CDD:304357	42/317 (13%)
		HNOBA	<857..903	CDD:285003	13/45 (29%)
		CYCc	882..1073	CDD:214485	88/202 (44%)
		Guanylate_cyc	909..1095	CDD:278633	86/197 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810