DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and gcy-12

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_494995.2	Gene:	gcy-12 / 173902	WormBaseID:	WBGene00001538	Length:	1679	Species:	Caenorhabditis elegans

Alignment Length:	400	Identity:	126/400 - (31%)
Similarity:	196/400 - (49%)	Gaps:	76/400 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 FHLMFDRQ--MKI-VQAGKAVSRVIPRVAEENC-SLIEVVEAIR-----PHLQ-----LNFENIL 389
            ||.:|.|:  .|| ||.|.......|:.....| :|:|  :.:|     |:.:     |..:|
Worm   864 FHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVE--KTVRRVYSDPYFRPDTSDLEVQN-- 924

  Fly   390 SHINTIYVLQTRQGAMSSRHEQR--FLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISD 452
                  ||.:...........||  |..:|.::       :.||.              .:|..:
Worm   925 ------YVKEVMAACWHHDPYQRPEFKTIKNKL-------KPLFH--------------QIYKQN 962

  Fly   453 VPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELR 517
            :..|     :||:.||::.:      ||.|.|  ::|. :|:.|::::..||..:||.|||.:|.
Worm   963 IMDH-----MVLMMEKYQTQ------LEDLVD--ERTI-ELKDEQRRSQHLLQRMLPSSVAEQLL 1013

  Fly   518 HQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKV 582
            ..:.|.|:.:..||:.||.||||......:|    .|::|..||:|||:||::.   |..:||||
Worm  1014 AGQDVIPEAFPPVTIYFSDIVGFTTISGEST----PMEVVTFLNKLYTLFDSII---RRYDVYKV 1071

  Fly   583 ETVGDKYMAVSGLPDH--CEDHAKCMARVALDMMDMAKNVKM---GSNPVQITIGIHSGEVVTGV 642
            ||:||.||.|||:|.:  .|.||:.:|.:|:.::...::..:   ...|:.|.||:|:|..|.||
Worm  1072 ETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEPLMIRIGMHTGPCVAGV 1136

  Fly   643 IGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPT 707
            :|..:|||.|||:|||..||.|:.|...||:.|..|.::|   .:.|..|.||.||.:.:|||..
Worm  1137 VGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVL---TSIDQGFLLEERGSLAIKGKGQ 1198

  Fly   708 PMDCWFLTRA 717
            ....|...||
Worm  1199 MTTYWLNGRA 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	45/192 (23%)
		CYCc	496..688	CDD:214485	77/196 (39%)
		Guanylate_cyc	522..714	CDD:278633	78/196 (40%)
gcy-12	NP_494995.2	PBP1_Speract_GC_like	123..545	CDD:107365
		ANF_receptor	140..519	CDD:279440
		PK_GC-A_B	648..957	CDD:270944	25/123 (20%)
		TyrKc	688..951	CDD:197581	23/96 (24%)
		HNOBA	<967..1012	CDD:285003	18/53 (34%)
		CYCc	991..1183	CDD:214485	78/201 (39%)
		Guanylate_cyc	1018..1206	CDD:278633	78/197 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810