Protein Alignment Gycbeta100B and gcy-35

DIOPT Version :10

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001252131.1
• Gene: gcy-35 / 173202
• WormBaseID: WBGene00001555
• Length: 688
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 209/726 - (28%)
• Similarity: 359/726 - (49%)
• Gaps: 136/726 - (18%)

  Fly     1 MYGFVNYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            |:|:::.:...||.:.:|::|||||...:...:..:..:...|:|:.|..|:.:...::.||.::
 Worm     1 MFGWIHESFRQLVTRKYGKDIWEKIVHMSKFELGTESEIAHYYNDDETLRLVNSMANVIGIPIEE 65

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALH---DHLGTLY-PGMRAPSFRC-TEK 125
            |.|.:|....:|..::|:|::|:.:......||.:||:||   ||:  :| ..:|.||||| .:.
 Worm    66 IWEAYGGFLIQFTMETGWDELLRAMAPDLEGFLDSLDSLHYFIDHV--VYKTKLRGPSFRCDVQA 128

  Fly   126 DGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLE 190
            ||.|||||||:|.||..||.|:|:.||.:::..||.:.:.:||.|.:|....|..:....|  :|
 Worm   129 DGTLLLHYYSKRSGLYPIVKGVVREVARRIYDTEVVMKVQERKQEHLDAFVTEHVVFVITQ--IE 191

  Fly   191 DAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIA 255
            :|                                              |:...:.|:|:.|..|.
 Worm   192 NA----------------------------------------------NSTQPKSISSKADSQID 210

  Fly   256 LSTCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDME 320
            |||           |..|
 Worm   211 LST-----------GIYE----------------------------------------------- 217

  Fly   321 FLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNF 385
                   ||.:.|...||:|:.||..:.:...|..:.:..|....:...:.:::|.:.|.:..::
 Worm   218 -------ISSSDFSLAFPYHICFDPDLFVEHFGNFIKKTFPNAMRQETRVTDLLELVHPEVPFSY 275

  Fly   386 ENILSHINTIYVLQTR---QGAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKG 447
            |:|..:.|:::|.:.:   ....::..|.:.:.|||.|::|.|...||:.|..:|..:.:|.::.
 Worm   276 ESIKYYKNSLFVFRLKGLGDIVHNANDEAKTVLLKGSMVFIDEGKYILYMCSVNVTTVRELIERN 340

  Fly   448 LYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSV 512
            |::||:..||..||:::|::...::.:|.:.||..|.||::..::||.||||||.||..::|.||
 Worm   341 LHLSDMQRHDGTRDVIMLNQSRMSQVELNRTLEETTKKLKKMAQELEIEKQKTDELLCELMPASV 405

  Fly   513 ANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNL 577
            |:.||..:.:..|.:...||:|:.||.|...||..|..|    :|.:||:||..||.|....
 Worm   406 ADSLRSGKAMDAKEFADCTLLFTDIVTFTNICAMCTPYD----VVTLLNDLYLRFDRLVGLH--- 463

  Fly   578 NVYKVETVGDKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNV--KMGSNPVQITIGIHSGEVVT 640
            :.|||||:||.||.|.|:|:.||:||:.:..:::.|:..:|.|  .:...|::|.:|:|.|.||.
 Worm   464 DAYKVETIGDAYMIVGGVPERCENHAERVLNISIGMLMESKLVLSPITHKPIKIRLGVHCGPVVA 528

  Fly   641 GVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGK 705
            ||:|.::|||||||:|||:.::.|:.|:..:|:|| ||.:|  ..:..:.|:....||...::||
 Worm   529 GVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVS-ETGKL--NGLKANPSYVFIDRGNTEIRGK 590

  Fly   706 PTPMDCWFLTR 716
            .. |..:||.|
 Worm   591 GM-MYTYFLER 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:462233	57/166 (34%)
		HNOBA	326..516	CDD:462234	56/192 (29%)
		Guanylate_cyc	522..714	CDD:425528	72/193 (37%)
gcy-35	NP_001252131.1	HNOB	3..167	CDD:462233	57/165 (35%)
		HNOBA	218..409	CDD:462234	56/190 (29%)
		CYCc	388..579	CDD:214485	81/200 (41%)