DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Gucy2e

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_036012232.1	Gene:	Gucy2e / 14919	MGIID:	105123	Length:	1139	Species:	Mus musculus

Alignment Length:	343	Identity:	125/343 - (36%)
Similarity:	180/343 - (52%)	Gaps:	56/343 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 ETDRILFQC---YPSVMNLDDLT-------KKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNL 479
            |..:::.||   :|.:....|||       .||            |...::........:.:.||
Mouse   813 ECIQLMTQCWAEHPELRPSMDLTFDLFKSINKG------------RKTNIIDSMLRMLEQYSSNL 865

  Fly   480 EMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYC 544
            |   |.:::...:||.|||||||||..:||.|||..|:....|.|:.::.|||.||.|||| ...
Mouse   866 E---DLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGF-TTI 926

  Fly   545 AANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLPD-HCEDHAKCMAR 608
            :|.::|   :::|.:||:|||:|||:..:.   :||||||:||.||..||||. :.:.||..:|.
Mouse   927 SAMSEP---IEVVDLLNDLYTLFDAIIGAH---DVYKVETIGDAYMVASGLPQRNGQRHAAEIAN 985

  Fly   609 VALDMMDMAKNVK---MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPG 670
            ::||::....:.:   |...||:|.||:|||..|.||:|..:|||||||:|||..||.|:||:|.
Mouse   986 MSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1050

  Fly   671 RINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGG 735
            ||:|:..|.|:| .|:  |..|.:|.||...:|||......|.:.|.                |.
Mouse  1051 RIHVNMSTVRIL-RAL--DQGFQMECRGRTELKGKGIEDTYWLVGRL----------------GF 1096

  Fly   736 NGSLDSPL-LQPATPTAG 752
            |..:..|. |||.....|
Mouse  1097 NKPIPKPPDLQPGASNHG 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	30/100 (30%)
		CYCc	496..688	CDD:214485	92/195 (47%)
		Guanylate_cyc	522..714	CDD:278633	86/195 (44%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594
		PK_GC-2D	570..845	CDD:270945	7/31 (23%)
		HNOBA	<854..899	CDD:400168	20/47 (43%)
		CYCc	879..1070	CDD:214485	93/200 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810