DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Gucy2d

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001124165.1	Gene:	Gucy2d / 14918	MGIID:	106030	Length:	1117	Species:	Mus musculus

Alignment Length:	265	Identity:	109/265 - (41%)
Similarity:	158/265 - (59%)	Gaps:	37/265 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   475 LTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVG 539
            |.|..|.|.|.:|:...:||.|::||:|||..:||.|||:.|:....|.|:.:|.||:.||.|||
Mouse   831 LEKYSESLEDLVQERTEELELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVG 895

  Fly   540 FGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP-DHCEDHA 603
            | ...:|.::|   :::|..||:|||:|||:.||.   :||||||:||.||..|||| .:...||
Mouse   896 F-TTISALSEP---IEVVGFLNDLYTLFDAVLDSH---DVYKVETIGDAYMVASGLPRRNGNRHA 953

  Fly   604 KCMARVALDMMDMAKNVKM---GSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTET 665
            ..:|.:|||::..|.|.:|   ...|:::..|:|||..|.||:|..:|||||||:|||..||.|:
Mouse   954 AEIANLALDILSYAGNFRMRHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMES 1018

  Fly   666 TGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGK------------------PTPM--- 709
            ||:|.||:||:.|.:.|   ::.|:.:.::.||...:|||                  |||:
Mouse  1019 TGLPYRIHVSQSTVQAL---LSLDEGYKIDVRGQTELKGKGLEETYWLTGKVGFCRPLPTPLSIK 1080

  Fly   710 --DCW 712
              |.|
Mouse  1081 PGDPW 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	19/40 (48%)
		CYCc	496..688	CDD:214485	90/195 (46%)
		Guanylate_cyc	522..714	CDD:278633	89/218 (41%)
Gucy2d	NP_001124165.1	PBP1_sensory_GC_DEF-like	71..445	CDD:380594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..557
		PK_GC-2D	554..818	CDD:270945
		CYCc	855..1044	CDD:214485	90/198 (45%)
		Interaction with NCALD. /evidence=ECO:0000250\|UniProtKB:P51839	874..915		16/44 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910