DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Gucy2c

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	504	Identity:	138/504 - (27%)
Similarity:	214/504 - (42%)	Gaps:	124/504 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 QFLIREINVAAK--SQVDAKKDEVPDDM----------------EFLCEAPLISPATFCKVFPFH 340
            :|.|..:|..||  |.:.:.|.||...:                :|.|.: ::.|.......|.|
Mouse   588 EFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNS-ILPPKKDLWTAPEH 651

  Fly   341 LMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAM 405
            |   ||..|.|.|...|..|  :|:|                     |:....|.|.|..|.
Mouse   652 L---RQATISQKGDVYSFAI--IAQE---------------------IILRKETFYTLSCRD--- 687

  Fly   406 SSRHEQRFLRLKGQM-------MYIPETDRILFQCY--------------PSVMNLDDLTKK--G 447
               |.::..|::...       :::...|....:.|              |....::....|  |
Mouse   688 ---HNEKIFRVENSYGKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFG 749

  Fly   448 LYISDVPLHDAARDLVL--LSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPK 510
            |:      ||...:..:  |..:.:.   .::|||.|.::..|.::   :|:.:.|.|.:.:||:
Mouse   750 LF------HDQKNESYMDTLIRRLQL---YSRNLEHLVEERTQLYK---AERDRADHLNFMLLPR 802

  Fly   511 SVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKR 575
            .|...|:.:..|.|:.|:.||:.||.||||...|..:|    .|::|.|||::|..||.:.|
Mouse   803 LVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDQIVD--- 860

  Fly   576 NLNVYKVETVGDKYMAVSGLP-DHCEDHAKCMARVALDMMDMAKNVK---MGSNPVQITIGIHSG 636
            :.:||||||:||.|:..|||| .:...||..::::|||::......:   :...||.|.||:|||
Mouse   861 HHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFIGTFELEHLPGLPVWIRIGVHSG 925

  Fly   637 EVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVI 701
            ....||:|.::|||||||:|||..||.|:||:|.||::|..|..:|   ...|..|..|.||...
Mouse   926 PCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTITIL---KRTDCQFLYEVRGETY 987

  Fly   702 MKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGGNGSLDSPLLQPATPT 750
            :||:.|....|.                      .|..|.....|:.||
Mouse   988 LKGRGTETTYWL----------------------TGMKDQEYNLPSPPT 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	40/214 (19%)
		CYCc	496..688	CDD:214485	79/195 (41%)
		Guanylate_cyc	522..714	CDD:278633	81/195 (42%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141
		PKc_like	480..749	CDD:304357	35/193 (18%)
		STYKc	502..744	CDD:214568	34/188 (18%)
		CYCc	787..978	CDD:214485	80/200 (40%)
		Guanylate_cyc	814..1001	CDD:278633	81/218 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810