DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and gucy2d

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	464	Identity:	150/464 - (32%)
Similarity:	217/464 - (46%)	Gaps:	106/464 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 KDEVPDDM-----EFLCEAPLISPATF-CKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSL 370
            :|..|:|.     |.|....|....|: ..|:.|.::..         :.:||..|     .|.|
Zfish   737 EDNAPEDQFWTAPEILRNPDLKKKGTYPGDVYSFSIIMQ---------EVISRCAP-----FCML 787

  Fly   371 ----IEVVEAIRPHLQLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYIPETDRILF 431
                .|::|.:|....|....:......:.|:|..:.|.|...|||            .|...:|
Zfish   788 DMPPEEIIEKVRSPPPLCRPTVSMDEAPLDVIQLMKQAWSEEPEQR------------PTFEDIF 840

  Fly   432 QCYPSVMNLDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESE 496
            :.:.| ||....|.    |.|        .::.:.|::      :.|||   |.:::...:||.|
Zfish   841 RQFKS-MNKGKKTN----IID--------SMLRMLEQY------SSNLE---DLIRERTEELEVE 883

  Fly   497 KQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLN 561
            :||||.||..:||||||..|:..:||.|:.:..|||.||.|||| ...:|.::|   :::|.:||
Zfish   884 RQKTDALLAQMLPKSVALALKTGKPVKPEHFAEVTLYFSDIVGF-TTISALSEP---IEVVDLLN 944

  Fly   562 ELYTVFD---ALTDSKRNLNVYKVETVGDKYMAVSGLPD-HCEDHAKCMARVALDMMDMAKNVKM 622
            :|||.||   |:.|      ||||||:||.||..||:|: :...||..||.::||::......||
Zfish   945 DLYTHFDGIIAIHD------VYKVETIGDAYMVASGVPNRNGTRHAAEMANMSLDILHCIGTFKM 1003

  Fly   623 GSNP---VQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCM 684
            ...|   |:|.||:|||.||.||:|.::|||||||:|||..||.|:||:|.||:|::.|..:|
Zfish  1004 RHMPDVKVKIRIGLHSGPVVAGVVGLKMPRYCLFGDTVNTASRMESTGLPYRIHVNQSTVDVL-- 1066

  Fly   685 AINQDDSFHLEY----RGPVIMKGKPTPMDCWFLTRATSSILGGTSSTGGSGGGGNGSLDSPLLQ 745
                 :|..|.|    ||...:|||......|.:                    |....|.||..
Zfish  1067 -----NSLKLGYKIDTRGRTELKGKGVEETFWLV--------------------GRDGFDKPLPI 1106

  Fly   746 PATPTAGAA 754
            |...|.||:
Zfish  1107 PPDLTPGAS 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	48/194 (25%)
		CYCc	496..688	CDD:214485	93/198 (47%)
		Guanylate_cyc	522..714	CDD:278633	87/202 (43%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366
		PK_GC-2D	581..849	CDD:270945	30/138 (22%)
		HNOBA	<858..903	CDD:311573	20/53 (38%)
		CYCc	883..1075	CDD:214485	96/208 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910