DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and gucy2f

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	246	Identity:	103/246 - (41%)
Similarity:	155/246 - (63%)	Gaps:	17/246 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 TKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGF 540
            :.|||   |.:::...:||.|||:|::||..:||.|||..|:....|.|:.:|.||:.||.||||
Zfish   833 SSNLE---DLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVTIYFSDIVGF 894

  Fly   541 GQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGLP-DHCEDHAK 604
             ...::.:||   :::|.:||:||::|||:..|.   :||||||:||.||..|||| .:...||.
Zfish   895 -TTISSLSDP---IEVVDLLNDLYSLFDAVLGSH---DVYKVETIGDAYMVASGLPKKNGNKHAA 952

  Fly   605 CMARVALDMMDMAKNVK---MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETT 666
            .:|.::|:::....:.|   |...||:|.||||||..|.||:|..:|||||||:|||..||.|:|
Zfish   953 EIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRMEST 1017

  Fly   667 GVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCWFLTRA 717
            |:|.||:|:..|.::| .::|  |.:.::.||...:|||......|.:.:|
Zfish  1018 GLPYRIHVNISTVQIL-RSLN--DGYKIDVRGKTELKGKGIEETYWLVGKA 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	17/39 (44%)
		CYCc	496..688	CDD:214485	88/195 (45%)
		Guanylate_cyc	522..714	CDD:278633	84/195 (43%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366
		PK_GC-2D	551..816	CDD:270945
		HNOBA	<825..870	CDD:311573	17/39 (44%)
		CYCc	850..1042	CDD:214485	90/201 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810