DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and LRRK2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens

Alignment Length:	840	Identity:	161/840 - (19%)
Similarity:	268/840 - (31%)	Gaps:	320/840 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLKHFGEEIWEKIKKKAMVSM------------EGQFLVRQIYDDEITYNLIGAAVEILNIPADD 65
            ||..|.|  |..|...:|.|:            ||.|||::      ..|.|...
Human   868 VLSKFDE--WTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKK------KSNSISVG---------- 914

  Fly    66 ILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHLGTLY---------PGMRAPSFR 121
                      ||.:|:    :||......:....:|..:.||...|.         ..:|:...:
Human   915 ----------EFYRDA----VLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKILSSDDSLRSSKLQ 965

  Fly   122 CTEKDGELLLHYYSERPGLEHIVIGIVKAVASKLHGVEVEIDIVKRK---GEPIDEAEK----ER 179
            ...:..:.:....|||..:..:.:.     |::|.    :||.:.:|   ...::..||    :.
Human   966 SHMRHSDSISSLASEREYITSLDLS-----ANELR----DIDALSQKCCISVHLEHLEKLELHQN 1021

  Fly   180 AIARENQQLLE--------DAVATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVN 236
            |:....|||.|        |..:...|...:.:|..|.                  :||    ::
Human  1022 ALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSC------------------IAN----LD 1064

  Fly   237 VNNNNDGQQIASETDPSIALSTCPIAQ-----------------------DSFDCDGD------- 271
            |:.|:.|..:.  .||::   .||..:                       :....:|:
Human  1065 VSRNDIGPSVV--LDPTV---KCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICS 1124

  Fly   272 ----KEQKCLRLLKNKSDDIERYDHVQFLIREINVAAKSQVDAKKDEVPDDMEFLCEAPLISPAT 332
                ||.|.|.|.||         |:..|......|.     .|.:.....|.||...|.:.|
Human  1125 PLRLKELKILNLSKN---------HISSLSENFLEAC-----PKVESFSARMNFLAAMPFLPP-- 1173

  Fly   333 FCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAI--RPHLQ------------- 382
                                    |..|.::::...|.|.  |||  .|||:
Human  1174 ------------------------SMTILKLSQNKFSCIP--EAILNLPHLRSLDMSSNDIQYLP 1212

  Fly   383 -------LNFENILSHINTIYVLQTRQGA-MSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMN 439
                   ||...:|...|.|.:|...:.| :.||.|:..|. ..::..||          |.:..
Human  1213 GPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLS-HNKLKEIP----------PEIGC 1266

  Fly   440 LDDLTKKGLYISDVPLHDAARDLVLLSEKFEAEY-KLTKNLEMLTDKLQQT--FRDLESEKQKTD 501
            |::||..          |.:.:|.|.|  |..|. ||:|..::..|:|...  |:.:..:.:...
Human  1267 LENLTSL----------DVSYNLELRS--FPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDII 1319

  Fly   502 RLLYSVLPKSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTV 566
            |.|...|.|:|.             |:.:.||..|..|.|:                     .|:
Human  1320 RFLQQRLKKAVP-------------YNRMKLMIVGNTGSGK---------------------TTL 1350

  Fly   567 FDALTDSKRNLNVYKVETVG----------------DKYMAV---SGLPDHCEDHAKCMARVA-- 610
            ...|..:|::....:..|||                |..:.|   :|..:....|...|.:.|
Human  1351 LQQLMKTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALY 1415

  Fly   611 LDMMDMAK-------------NVK--MGSNPVQITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLT 660
            |.:.|::|             |:|  ..|:|| |.:|.|     ..|...:..:.|:...|..|.
Human  1416 LAVYDLSKGQAEVDAMKPWLFNIKARASSSPV-ILVGTH-----LDVSDEKQRKACMSKITKELL 1474

  Fly   661 SRTETTGVPG-----RINVSEET---YRLLCMAINQDDSFHLEYRGPVIMKGKPTPMDCW 712
            ::   .|.|.     .:|.:||:   .:|....||  :|.:.:.|..::: |:..| ||:
Human  1475 NK---RGFPAIRDYHFVNATEESDALAKLRKTIIN--ESLNFKIRDQLVV-GQLIP-DCY 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	31/171 (18%)
		HNOBA	326..516	CDD:285003	46/215 (21%)
		CYCc	496..688	CDD:214485	45/235 (19%)
		Guanylate_cyc	522..714	CDD:278633	47/235 (20%)
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969		25/132 (19%)
		LRR 1	983..1004		4/29 (14%)
		leucine-rich repeat	985..1012	CDD:275380	5/35 (14%)
		LRR	1012..>1286	CDD:227223	69/365 (19%)
		LRR 2	1012..1033		6/20 (30%)
		leucine-rich repeat	1013..1036	CDD:275380	7/22 (32%)
		LRR 3	1036..1057		3/20 (15%)
		leucine-rich repeat	1037..1084	CDD:275380	12/73 (16%)
		LRR 4	1059..1080		7/44 (16%)
		LRR 5	1084..1105		0/20 (0%)
		leucine-rich repeat	1085..1108	CDD:275380	0/22 (0%)
		LRR 6	1108..1129		1/20 (5%)
		leucine-rich repeat	1109..1130	CDD:275380	1/20 (5%)
		LRR 7	1130..1150		8/28 (29%)
		leucine-rich repeat	1131..1174	CDD:275380	14/82 (17%)
		LRR 8	1174..1196		7/23 (30%)
		leucine-rich repeat	1175..1197	CDD:275380	6/23 (26%)
		LRR 9	1197..1218		2/20 (10%)
		leucine-rich repeat	1198..1221	CDD:275380	1/22 (5%)
		LRR 10	1221..1241		5/19 (26%)
		leucine-rich repeat	1222..1246	CDD:275380	5/23 (22%)
		LRR 11	1246..1267		6/31 (19%)
		leucine-rich repeat	1247..1269	CDD:275380	6/32 (19%)
		LRR 12	1269..1291		8/33 (24%)
		RocCOR	1334..1507	CDD:206741	40/204 (20%)
		COR	1527..1740	CDD:318343	0/1 (0%)
		STKc_LRRK2	1884..2135	CDD:270970
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900