DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Adcy9

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	251	Identity:	82/251 - (32%)
Similarity:	135/251 - (53%)	Gaps:	22/251 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 LSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLPKSVANELRHQRPVPPKRYDS 529
            |:.:||..|:|..:.::..| |.:|  .::|.:.:.|.||.:::|..||.:|:..:.. .|.:||
Mouse  1015 LNREFEVSYRLHYHGDVEAD-LHRT--KIQSMRDQADWLLRNIIPYHVAEQLKVSQTY-SKNHDS 1075

  Fly   530 VTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSG 594
            ..::|:.||.|.::...|.  :|..:..::||||...||.|.......::.|::|:|..|||.||
Mouse  1076 GGVIFASIVNFSEFYEENY--EGGKECYRVLNELIGDFDELLSKPDYNSIEKIKTIGATYMAASG 1138

  Fly   595 L-------PDHCEDHAKCMARVALDMM---DMAKNVKMGSNPVQITIGIHSGEVVTGVIGNRVPR 649
            |       ..|.::|.:.:...|.:||   |...|..:..| .::.:|.:.|.:..||||.....
Mouse  1139 LNTAQCQEGGHPQEHLRILFEFAKEMMRVVDDFNNNMLWFN-FKLRVGFNHGPLTAGVIGTTKLL 1202

  Fly   650 YCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGK 705
            |.::|:|||:.||.:||||..||.||||:||:|...     .:..:|||.|.:|||
Mouse  1203 YDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKM-----GYDFDYRGTVNVKGK 1253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	15/50 (30%)
		CYCc	496..688	CDD:214485	66/201 (33%)
		Guanylate_cyc	522..714	CDD:278633	66/194 (34%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944
		Guanylate_cyc	385..573	CDD:306677
		Guanylate_cyc	1069..1260	CDD:306677	66/194 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810