DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Adcy8

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus

Alignment Length:	850	Identity:	182/850 - (21%)
Similarity:	332/850 - (39%)	Gaps:	233/850 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFFE--------FCQDSG 82
            :::.::|:..:|:|.::.:|            :.|:..:.:...|.:.:..        |....|
Mouse   368 QERLVLSVLPRFVVLEMIND------------MTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 420

  Fly    83 YDKILQVLGATPRDFLQNLDAL--------HDH-------LGTLY------PGMRAPSFRCTEKD 126
            :..:...|.|  ::.::.|:.|        |:|       ||..|      |..|.....|..:.
Mouse   421 FTNLSTTLSA--QELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEM 483

  Fly   127 GELLL-----------HYYSERPGLEHI------VIGIVK----------AVASKLH--GVEVEI 162
            |..::           |....|.|: |.      |:|:.|          .:|:||.  |:...|
Mouse   484 GLSMIKTIRFVRSRTKHDVDMRIGI-HSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRI 547

  Fly   163 DIVKR-----KGE-PIDEAE-KER------------AIARENQQLL---EDAV------------ 193
            .|.|.     .|: .::|.. |||            .|.:..:.||   ||.|
Mouse   548 HISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNS 612

  Fly   194 -ATTTTGSATVVLAPSSDAERNNNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALS 257
             ||.|.||.:..|.          .:...|..|...|...|::|:..|:..|.:..::.|.
Mouse   613 GATFTEGSWSPELP----------FDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPE---- 663

  Fly   258 TCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAK-SQVDAKKDEVPDD--- 318
                         :..::....:..:|.|..|.:|    |:..::..| |.::.|..::.|:
Mouse   664 -------------EINKRIEHTIDLRSGDKLRREH----IKPFSLMFKDSSLEHKYSQMRDEVFK 711

  Fly   319 ---------MEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVS-----RVIPRVAEENCS 369
                     :.|:.....:.|::  ::.|..:.|...:.:..|...::     :.:|.:..:.|.
Mouse   712 SNLVCAFIVLLFITAIQSLLPSS--RLMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCC 774

  Fly   370 -----------------LIEVVEAIRPHLQLNFE------NILSHINTI---------YVLQTRQ 402
                             ||..:.|:...|..:|:      |:..:.:.:         |.:.|
Mouse   775 WINETYLARNVIIFASILINFLGAVLNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT-- 837

  Fly   403 GAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARDL----- 462
            |.::......||||...:..     .:|.........|.:....||::|...|:.:..|.
Mouse   838 GVLAMVTCAVFLRLNSVLKL-----AVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDFLGTKE 897

  Fly   463 --VLLSEKF---------EAEYKLTKNLEML-TDKLQQTFRDLESEKQKTDRLLYSVLPKSVANE 515
              :||...|         :.||  |..|:.| ..:.::...:::..::..:.:|.::||..||..
Mouse   898 ASLLLMAMFLLAVFYHGQQLEY--TARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARH 960

  Fly   516 L----RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRN 576
            .    |....:..:.||:|.:||:.|.||..:.:.....:..::.:::|||:...||.|....|.
Mouse   961 FLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRF 1025

  Fly   577 LNVYKVETVGDKYMAVSGL-PD--HCED---HAKCMARVALDMMDMAKNV-KMGSNPVQITIGIH 634
            .::.|::|:|..||||||| |:  .|||   |...:|..:|.:.:..:.: |...|..::.|||.
Mouse  1026 QDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGIS 1090

  Fly   635 SGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGP 699
            .|.||.||||.:.|:|.::|.||||.||.::|||.|||.|.||||.:|     :|..|..:|||.
Mouse  1091 HGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL-----KDQGFAFDYRGE 1150

  Fly   700 VIMKG 704
            :.:||
Mouse  1151 IYVKG 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	33/195 (17%)
		HNOBA	326..516	CDD:285003	39/243 (16%)
		CYCc	496..688	CDD:214485	71/202 (35%)
		Guanylate_cyc	522..714	CDD:278633	71/189 (38%)
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118
		AC_N	<159..398	CDD:292831	5/41 (12%)
		CYCc	364..562	CDD:214485	36/208 (17%)
		Guanylate_cyc	403..587	CDD:278633	35/186 (19%)
		DUF1053	615..709	CDD:283888	22/124 (18%)
		CYCc	942..1146	CDD:214485	73/208 (35%)
		Guanylate_cyc	971..1170	CDD:278633	71/189 (38%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		25/53 (47%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900