DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and Adcy6

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	XP_006520366.3	Gene:	Adcy6 / 11512	MGIID:	87917	Length:	1254	Species:	Mus musculus

Alignment Length:	291	Identity:	100/291 - (34%)
Similarity:	154/291 - (52%)	Gaps:	30/291 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   449 YISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQK--TDRLLYSVLPKS 511
            |::.|.|...|..|.|.:::.|:    |..|:.|. |||.|....|.|:.:  ..|||:::|||.
Mouse   982 YMTPVILLVFALALYLHAQQVES----TARLDFLW-KLQATGEKEEMEELQAYNRRLLHNILPKD 1041

  Fly   512 V-ANELRHQRPVPPKRYDS---VTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTD 572
            | |:.|..:|......|.|   |.:||:.|..|.::.......:..::.:::|||:...||.:..
Mouse  1042 VAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1106

  Fly   573 SKRNLNVYKVETVGDKYMAVSGLPDHCED-----HAKCMARVALDMMDMAKNVKMGS-NPVQITI 631
            .:|...:.|::|:|..|||.|||.....|     |...:|..|:.:|:..|::...| |..|:.|
Mouse  1107 EERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNFQMKI 1171

  Fly   632 GIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEY 696
            |::.|.||.||||.|.|:|.::|||||::||.::||||.||.|:.:.|::|..     ..:.||.
Mouse  1172 GLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAA-----KGYQLEC 1231

  Fly   697 RGPVIMKGKPTPMDCWFLTRATSSILGGTSS 727
            ||.|.:||| ..|..:||.       ||.||
Mouse  1232 RGVVKVKGK-GEMTTYFLN-------GGPSS 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	24/69 (35%)
		CYCc	496..688	CDD:214485	70/203 (34%)
		Guanylate_cyc	522..714	CDD:278633	68/200 (34%)
Adcy6	XP_006520366.3	AC_N	83..454	CDD:318454
		Guanylate_cyc	456..640	CDD:306677
		DUF1053	668..754	CDD:368844
		Guanylate_cyc	1056..1250	CDD:306677	70/206 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810