DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gycbeta100B and ADCY8

DIOPT Version :9

Sequence 1:NP_524603.2 Gene:Gycbeta100B / 43682 FlyBaseID:FBgn0013973 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_001106.1 Gene:ADCY8 / 114 HGNCID:239 Length:1251 Species:Homo sapiens


Alignment Length:850 Identity:182/850 - (21%)
Similarity:330/850 - (38%) Gaps:233/850 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFFE--------FCQDSG 82
            :::.::|:..:|:|.::.:|            :.|:..:.:...|.:.:..        |....|
Human   370 QERLVLSVLPRFVVLEMIND------------MTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422

  Fly    83 YDKILQVLGATPRDFLQNLDAL--------HDH-------LGTLY------PGMRAPSFRCTEKD 126
            :..:...|.|  ::.::.|:.|        |:|       ||..|      |..|.....|..:.
Human   423 FTNLSTTLSA--QELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEM 485

  Fly   127 GELLL-----------HYYSERPGLEHI------VIGIVK----------AVASKLH--GVEVEI 162
            |..::           |....|.|: |.      |:|:.|          .:|:||.  |:...|
Human   486 GLSMIKTIRYVRSRTKHDVDMRIGI-HSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRI 549

  Fly   163 DIVKR-----KGE-PIDEAE-KER------------AIARENQQLL---EDAVATTTTGSATVVL 205
            .|.|.     .|: .::|.. |||            .|.:....||   ||.|..:.        
Human   550 HISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESV-------- 606

  Fly   206 APSSDAERNNNHNGSNGS-------------NNNGMANNGNTVNVNNNNDGQQIASETDPSIALS 257
              ||...||:....:.||             .|...|...|::|:..|:..|.:..::.|.    
Human   607 --SSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPE---- 665

  Fly   258 TCPIAQDSFDCDGDKEQKCLRLLKNKSDDIERYDHVQFLIREINVAAK-SQVDAKKDEVPDD--- 318
                         :..::....:..:|.|..|.:|    |:..::..| |.::.|..::.|:   
Human   666 -------------EINKRIEHTIDLRSGDKLRREH----IKPFSLMFKDSSLEHKYSQMRDEVFK 713

  Fly   319 ---------MEFLCEAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVS-----RVIPRVAEENCS 369
                     :.|:.....:.|::  :|.|..:.|...:.:..|...::     :.:|.:..:.|.
Human   714 SNLVCAFIVLLFITAIQSLLPSS--RVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCC 776

  Fly   370 -----------------LIEVVEAIRPHLQLNFE------NILSHINTI---------YVLQTRQ 402
                             ||..:.||...|..:|:      |:..:.:.:         |.:.|  
Human   777 WINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFT-- 839

  Fly   403 GAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPSVMNLDDLTKKGLYISDVPLHDAARDL----- 462
            |.::......||||...:..     .:|.........|.:....||::....|:.:..|.     
Human   840 GVLAMVTCAVFLRLNSVLKL-----AVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKE 899

  Fly   463 --VLLSEKF---------EAEYKLTKNLEML-TDKLQQTFRDLESEKQKTDRLLYSVLPKSVANE 515
              :||...|         :.||  |..|:.| ..:.::...:::..::..:.:|.::||..||..
Human   900 VSLLLMAMFLLAVFYHGQQLEY--TARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARH 962

  Fly   516 L----RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRN 576
            .    |....:..:.||:|.:||:.|.||..:.:.....:..::.:::|||:...||.|....|.
Human   963 FLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRF 1027

  Fly   577 LNVYKVETVGDKYMAVSGL-PD--HCED---HAKCMARVALDMMDMAKNV-KMGSNPVQITIGIH 634
            .::.|::|:|..||||||| |:  .|||   |...:|..:|.:.:..:.: |...|..::.|||.
Human  1028 QDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGIS 1092

  Fly   635 SGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGP 699
            .|.||.||||.:.|:|.::|.||||.||.::|||.|||.|.||||.:|     :|..|..:|||.
Human  1093 HGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL-----KDQGFAFDYRGE 1152

  Fly   700 VIMKG 704
            :.:||
Human  1153 IYVKG 1157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Gycbeta100BNP_524603.2 HNOB 2..164 CDD:285002 33/195 (17%)
HNOBA 326..516 CDD:285003 40/243 (16%)
CYCc 496..688 CDD:214485 71/202 (35%)
Guanylate_cyc 522..714 CDD:278633 71/189 (38%)
ADCY8NP_001106.1 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..182
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..109
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..92
AC_N <161..400 CDD:292831 5/41 (12%)
CYCc 366..564 CDD:214485 36/208 (17%)
Guanylate_cyc 405..589 CDD:278633 35/186 (19%)
DUF1053 617..711 CDD:283888 18/114 (16%)
CYCc 944..1148 CDD:214485 73/208 (35%)
Guanylate_cyc 973..1172 CDD:278633 71/189 (38%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1109..1251 25/53 (47%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1200..1215
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1223..1251
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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