Protein Alignment Gycbeta100B and ADCY3

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: XP_011530791.1
• Gene: ADCY3 / 109
• HGNCID: 234
• Length: 1186
• Species: Homo sapiens
• Alignment Length: 923
• Identity: 188/923 - (20%)
• Similarity: 327/923 - (35%)
• Gaps: 269/923 - (29%)

  Fly     6 NYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDE----ITYNLIGAAVEILNIPADDI 66
            |..|.:|. ||..:|:.:.:||......:.||....:|..|    :..:::|.........|.::
Human   277 NLMLSILP-KHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL 340

  Fly    67 LELFGKTFFEFCQDSGYDKI--------LQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT 123
            ::|..:.|..|      ||:        :::||          |..:...|  .|..|.....|:
Human   341 VKLLNELFARF------DKLAAKYHQLRIKILG----------DCYYCICG--LPDYREDHAVCS 387

  Fly   124 EKDGELL---LHYYSE--RPGLE-----H--IVIGIV--------------KAVASKLH------ 156
            ...|..:   :.|..|  :.|::     |  .|:|.|              ..||:|:.
Human   388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPG 452

  Fly   157 GVEVEIDIVKRKGEPIDEAEKERA-IARENQQLL--EDAVATTTTGS-----------ATVVLAP 207
            |.::|..:......|......||. |::.....|  |..|.....||           ..:::|.
Human   453 GSKIEERLYSCVVAPTLRLRWERVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIAS 517

  Fly   208 SSDAERNNNHNGSNGS---------------------NNNGMANNGNTVNVNNNNDGQQIASETD 251
            ..:.::....||.|||                     ..||.|::..:.:........|:...|.
Human   518 KPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQLFPTTL 582

  Fly   252 PSIALSTCPIAQDSFDCDGDKEQKCLRL--LKNKSDDIERYDH-VQFLIREINVAAKS-QVDAKK 312
            ..:..|.|.....:.:......::.|||  |.::..|....:| :..|:.|..:..:| ||..|:
Human   583 SHLPHSRCLPGSQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKR 647

  Fly   313 DEVPDDMEF----------------------------LCEA---PLISP---------------- 330
            :.....|.|                            ||.|   .||.|
Human   648 NTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILL 712

  Fly   331 ---------ATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPHL----- 381
                     |.|.:.||        .|:|.....:.|.  |.|....:::.:...:..::
Human   713 LILTICSLAAIFPRAFP--------KKLVAFSTWIDRT--RWARNTWAMLAIFILVMANVVDMLS 767

  Fly   382 --------------------------QLNFENILSHINTIYVLQTRQGAMSSRHEQRFLRLKGQM 420
                                      ..|:..:||.|.||.::|.          ...::|...:
Human   768 CLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQV----------SHMVKLTLML 822

  Fly   421 MYIPETDRILFQCYPSVMNLDDLTKKGLYISDVP-------------LHDAARDLVLLSEKFE-- 470
            :.......|....:..|  .|:...|.....|:|             |:.....|.|:..|:.
Human   823 LVAGAVATINLYAWRPV--FDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDSRLPLVPSKYSMT 885

  Fly   471 --------AEYKLTKNLEMLTDKLQQTFRDLESEKQK-------TDRLLYSVLPKSVANEL---- 516
                    :.|..::::|.|...|.....::..:|::       .:.|:.::||:.||...
Human   886 VMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSK 950

  Fly   517 RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYK 581
            :....:..:.||.:.:||:.:..|..:....:..:|.::.::.|||:.:.||:|.|:.:...:.|
Human   951 KRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITK 1015

  Fly   582 VETVGDKYMAVSGL-PD---------HCED--------HAKCMARVALDMMDMAKNVKMGS-NPV 627
            ::|:|..|||.||: ||         :.||        |...:|..||.|.|...|:...| |..
Human  1016 IKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNF 1080

  Fly   628 QITIGIHSGEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSF 692
            .:.||::.|.|:.||||.|.|.|.::|||||:.||.|:|||.|.|.|.|||..:|     ::..|
Human  1081 MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVIL-----REYGF 1140

  Fly   693 HLEYRGPVIMKGK 705
            ....|||:.:|||
Human  1141 RFVRRGPIFVKGK 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	39/201 (19%)
		HNOBA	326..516	CDD:285003	40/275 (15%)
		CYCc	496..688	CDD:214485	69/221 (31%)
		Guanylate_cyc	522..714	CDD:278633	70/203 (34%)
ADCY3	XP_011530791.1	AC_N	<44..303	CDD:292831	8/26 (31%)
		CYCc	273..490	CDD:214485	44/231 (19%)
		Guanylate_cyc	310..516	CDD:278633	38/223 (17%)
		CYCc	925..1143	CDD:214485	69/222 (31%)
		Guanylate_cyc	956..1163	CDD:278633	70/203 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810