DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gycbeta100B and ADCY2

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	223	Identity:	75/223 - (33%)
Similarity:	123/223 - (55%)	Gaps:	37/223 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 LQQTFRD----------LESEKQKTDRLLYSVLPKSVANELRH---QRPVPP------------- 524
            ||||::|          ||.||::.:|||.|:||..:|.|::.   ||...|
Human   216 LQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHN 280

  Fly   525 ---KRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVG 586
               ||:.:|:::::.||||.: .|::..|.   ::|.|||||:..||.:  :|.| ...:::.:|
Human   281 LYVKRHTNVSILYADIVGFTR-LASDCSPG---ELVHMLNELFGKFDQI--AKEN-ECMRIKILG 338

  Fly   587 DKYMAVSGLPDHCEDHAKCMARVALDMMDMAKNVKMGSN-PVQITIGIHSGEVVTGVIGNRVPRY 650
            |.|..|||||....:|||...::.|||.:..|.|:..:. .:.:.:|:|||.|:.||||.:..:|
Human   339 DCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQY 403

  Fly   651 CLFGNTVNLTSRTETTGVPGRINVSEET 678
            .::.:.|.|.:..|..|||||:::|..|
Human   404 DVWSHDVTLANHMEAGGVPGRVHISSVT 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002
		HNOBA	326..516	CDD:285003	16/39 (41%)
		CYCc	496..688	CDD:214485	68/203 (33%)
		Guanylate_cyc	522..714	CDD:278633	56/174 (32%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831	17/43 (40%)
		CYCc	236..439	CDD:214485	68/203 (33%)
		Guanylate_cyc	281..465	CDD:278633	55/158 (35%)
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485
		Guanylate_cyc	878..1077	CDD:278633
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810