DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gycbeta100B and Adcy3

DIOPT Version :9

Sequence 1:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	895	Identity:	190/895 - (21%)
Similarity:	332/895 - (37%)	Gaps:	254/895 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NYALELLVLKHFGEEIWEKIKKKAMVSMEGQFLVRQIYDDE----ITYNLIGAAVEILNIPADDI 66
            |..|.:|. ||..:|:.:.:||......:.||....:|..|    :..:::|.........|.::
Mouse   277 NLMLSILP-KHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQEL 340

  Fly    67 LELFGKTFFEFCQDSGYDKI--------LQVLGATPRDFLQNLDALHDHLGTLYPGMRAPSFRCT 123
            ::|..:.|..|      ||:        :::||          |..:...|  .|..|.....|:
Mouse   341 VKLLNELFARF------DKLAAKYHQLRIKILG----------DCYYCICG--LPDYREDHAVCS 387

  Fly   124 EKDGELL---LHYYSE--RPGLE-----H--IVIGIV--------------KAVASKLH--GVEV 160
            ...|..:   :.|..|  :.|::     |  .|:|.|              ..||:|:.  |:..
Mouse   388 ILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPG 452

  Fly   161 EIDIVKR-----KGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERNNNHNGS 220
            .:.|.:.     ||    |.:.|..........|::      .|..|.::..|....:....||.
Mouse   453 RVHISQSTMDCLKG----EFDVEPGDGGSRCDYLDE------KGIETYLIIASKPEVKKTAQNGL 507

  Fly   221 NGS---------------------NNNGMAN-NGNTVNVNNNNDGQQIASETDPSI-----ALST 258
            |||                     ..||.|: :|:|    :....:|.|...:||.     .|..
Mouse   508 NGSAVPNGAPASSKPSSPALIETKEPNGSAHASGST----SEEAEEQEAQADNPSFPNPRRRLRL 568

  Fly   259 CPIAQDSFDCDGDKEQ--KCLR--LLKNKSDDIERYDHVQFL-IREINVAAKSQVDAKKDEVPDD 318
            ..:|....|...|:.:  :.|.  ||:.:|..:.:..:...| :|.::...:::...:| |....
Mouse   569 QDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEK-EKQSG 632

  Fly   319 MEFLCEAP----------LISP-------------------------ATFCKVFPFHLMFDRQMK 348
            ..|.|...          ||.|                         |.|.:.||        .|
Mouse   633 AAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRSFP--------KK 689

  Fly   349 IVQAGKAVSRVIPRVAEEN-----------CSLIEVVEAIRPHL--------------------Q 382
            :|.....:.|.  |.|...           .::::::..::.::                    .
Mouse   690 LVAFSSWIDRT--RWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNMTAGMELDGGCMENPKY 752

  Fly   383 LNFENILSHINTIYVLQTRQ-----------GAMSSRHEQRFLRLKGQMMYIPETDRILFQCYPS 436
            .|:..:||.|.||.::|...           ||:::      |.|........|.|...||...|
Mouse   753 YNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTA------LNLYAWCPVFDEYDHKRFQEKDS 811

  Fly   437 VM----NLDDLTKKGLYISD--VPLHDAARDL-VLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLE 494
            .|    .:..|...||..:|  :||..:...: |::.....:.|..::::|.|...|.....::.
Mouse   812 PMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVH 876

  Fly   495 SEKQK-------TDRLLYSVLPKSVANEL----RHQRPVPPKRYDSVTLMFSGIVGFGQYCAANT 548
            .:|::       .:.|:.::||:.||...    :....:..:.||.:.:||:.:..|..:....:
Mouse   877 DQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEES 941

  Fly   549 DPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVETVGDKYMAVSGL-PD--------------- 597
            ..:|.::.::.|||:.:.||:|.|:.:...:.|::|:|..|||.||: ||
Mouse   942 INNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKS 1006

  Fly   598 ------HCEDHAKCMARVALDMMDMAKNVKMGS-NPVQITIGIHSGEVVTGVIGNRVPRYCLFGN 655
                  |..|    :|..||.|.|...|:...| |...:.||::.|.|:.||||.|.|.|.::||
Mouse  1007 DKERWQHLAD----LADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGN 1067

  Fly   656 TVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKGK 705
            |||:.||.|:|||.|.|.|.|||..:|     ::..|....|||:.:|||
Mouse  1068 TVNVASRMESTGVMGNIQVVEETQVIL-----REYGFRFVRRGPIFVKGK 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	38/197 (19%)
		HNOBA	326..516	CDD:285003	46/280 (16%)
		CYCc	496..688	CDD:214485	68/225 (30%)
		Guanylate_cyc	522..714	CDD:278633	69/207 (33%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	8/26 (31%)
		Guanylate_cyc	310..494	CDD:306677	36/211 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		14/63 (22%)
		Guanylate_cyc	915..1122	CDD:306677	69/207 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810