Protein Alignment Gycbeta100B and adcy8

DIOPT Version :9

• Sequence 1: NP_524603.2
• Gene: Gycbeta100B / 43682
• FlyBaseID: FBgn0013973
• Length: 787
• Species: Drosophila melanogaster
• Sequence 2: NP_001137224.1
• Gene: adcy8 / 100148976
• ZFINID: ZDB-GENE-070912-197
• Length: 1225
• Species: Danio rerio
• Alignment Length: 843
• Identity: 186/843 - (22%)
• Similarity: 326/843 - (38%)
• Gaps: 218/843 - (25%)

  Fly    26 KKKAMVSMEGQFLVRQIYDDEITYNLIGAAVEILNIPADDILELFGKTFFE--------FCQDSG 82
            :::.::|:..:|:|.::.:|            :.|:..:.:...|.:.:..        |....|
Zfish   344 QERLVLSVLPRFVVLEMIND------------MTNVEDETLQHQFHRIYIHRYENVSILFADVKG 396

  Fly    83 YDKILQVLGATPRDFLQNLDAL--------HDH-------LGTLY------PGMRAPSFRCTEKD 126
            :..:...|.|  ::.::.|:.|        |:|       ||..|      |..|.....|..:.
Zfish   397 FTNLSTTLSA--QELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEM 459

  Fly   127 GELLL-----------HYYSERPGLEHI------VIGIVK----------AVASKLH--GVEVEI 162
            |..::           |....|.|: |.      |:|:.|          .:|:||.  |:...|
Zfish   460 GLSMIKTIRYVRSRTKHDIDMRIGI-HSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRI 523

  Fly   163 DIVKRKGEPID-EAEKERAIARENQQLL-------------EDAVATTTTGSATVVLAPSS---D 210
            .|.|...:.:: :.|.|....::....|             |:::.|          .|..   |
Zfish   524 HISKAALDCLNGDYEVEEGHGKDRNDFLRRHNIETFLIKQPEESLLT----------LPEDIMRD 578

  Fly   211 AERNNNHNGSNGSNNNGMANN----GNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGD 271
            :...::|..||.|...|..:.    .|.|...|.     :|:.|..||.|....:||......|.
Zfish   579 STNQSDHRTSNTSFTEGTWSPELPFHNIVGKQNT-----LAALTRHSINLLPNHLAQALHVRAGS 638

  Fly   272 KE-----QKCLRLLKNKSDDIERYDHV---QFLIREINVAAK-SQVDAKKDEVPDDMEFLC---- 323
            :|     |..:.|   :|.|..|.:|:   ....||..:..| ||:   :||| .....:|
Zfish   639 QEINARMQSTIAL---RSGDKLRQEHISPFSLTFREALLEHKYSQM---RDEV-FKSNLVCAFIV 696

  Fly   324 -------EAPLISPATFCKVFPFHLMFDRQMKIVQAGKAVS-RVIPRVAEENCSLIEVVEAIRP- 379
                   ::.|.|......:..|.::......:|....|.. :.:|.|..:.|..:....|.|.
Zfish   697 LFFITGIQSLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKCLPLVLRKACCWVNETYAARNV 761

  Fly   380 ----HLQLNFENILSHINTIYVLQTRQGAMSSRHEQR---------------------------F 413
                .:.:||  :.:.||.::....:.|:..::....                           |
Zfish   762 VIFLSILINF--LAAMINILWCDFDKSGSFRNQTFNASASIPDICFYPEYFVFTGVLAMVTCAVF 824

  Fly   414 LRLKGQ-----MMYIPETDRILFQCY--PSVMNLDDLT----KKGLYISDVPLHDAARDLVLLSE 467
            |||...     ::.:.....:|.:.:  |..:..|.||    |..|...:..|        ||..
Zfish   825 LRLNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLNQSKSFLGTKETSL--------LLMA 881

  Fly   468 KF---------EAEYKLTKNLEML-TDKLQQTFRDLESEKQKTDRLLYSVLPKSVANEL----RH 518
            .|         :.||  |..|:.| ..:.::...::...::..:.:|.::||..||...    |.
Zfish   882 MFLLAVFYHGQQLEY--TARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEKDRD 944

  Fly   519 QRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSKRNLNVYKVE 583
            ...:..:.||:|.:||:.|.||..:.:.....:..::.:::|||:...||.|...:|..::.|::
Zfish   945 NEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIK 1009

  Fly   584 TVGDKYMAVSGL-PD--HCED---HAKCMARVALDMMDMAKNV-KMGSNPVQITIGIHSGEVVTG 641
            |:|..||||||| |:  .|||   |...:|..|:.:.:..:.: |...|..|:.||:..|.||.|
Zfish  1010 TIGSTYMAVSGLSPEKQQCEDKWGHLCALADFAIALNESIQEINKHSFNNFQLRIGMAHGSVVAG 1074

  Fly   642 VIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPVIMKG 704
            |||.:.|:|.::|.||||.||.::|||.|:|.:.||||     ||..:..|..||||.:.:||
Zfish  1075 VIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETY-----AILNERGFAFEYRGEIYVKG 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	33/195 (17%)
		HNOBA	326..516	CDD:285003	40/243 (16%)
		CYCc	496..688	CDD:214485	70/202 (35%)
		Guanylate_cyc	522..714	CDD:278633	71/190 (37%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	5/41 (12%)
		CYCc	340..538	CDD:214485	35/208 (17%)
		Guanylate_cyc	379..563	CDD:278633	32/186 (17%)
		DUF1053	592..685	CDD:283888	25/103 (24%)
		CYCc	919..1123	CDD:214485	71/208 (34%)
		Guanylate_cyc	948..1147	CDD:278633	71/190 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910